New insights into atypical Alzheimer's disease in the era of biomarkers

被引：446

作者：

Graff-Radford, Jonathan ^{[1
]}

Yong, Keir X. X. ^{[3
]}

Apostolova, Liana G. ^{[4
]}

Bouwman, Femke H. ^{[5
]}

Carrillo, Maria ^{[6
]}

Dickerson, Bradford C. ^{[7
,8
]}

Rabinovici, Gil D. ^{[9
]}

Schott, Jonathan M. ^{[3
]}

Jones, David T. ^{[1
,2
]}

Murray, Melissa E. ^{[10
]}

机构：

[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

[3] UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England

[4] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA

[5] Amsterdam Univ Med Ctr, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam, Netherlands

[6] Alzheimers Assoc, Chicago, IL USA

[7] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[8] Harvard Med Sch, Boston, MA 02115 USA

[9] Univ Calif San Francisco, Dept Neurol Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[10] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

来源：

LANCET NEUROLOGY | 2021年 / 20卷 / 03期

基金：

美国国家卫生研究院; 英国经济与社会研究理事会;

关键词：

POSTERIOR CORTICAL ATROPHY; DIAGNOSTIC-CRITERIA; BEHAVIORAL VARIANT; FRONTAL VARIANT; CLINICOPATHOLOGICAL CORRELATIONS; NEUROPATHOLOGIC ASSESSMENT; CLINICAL CHARACTERISTICS; CORTICOBASAL SYNDROME; NATIONAL INSTITUTE; BETA-DEPOSITION;

D O I：

10.1016/S1474-4422(20)30440-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Most patients with Alzheimer's disease present with amnestic problems; however, a substantial proportion, overrepresented in young-onset cases, have atypical phenotypes including predominant visual, language, executive, behavioural, or motor dysfunction. In the past, these individuals often received a late diagnosis; however, availability of CSF and PET biomarkers of Alzheimer's disease pathologies and incorporation of atypical forms ofAlzheimer's disease into new diagnostic criteria increasingly allows them to be more confidently diagnosed early in their illness. This early diagnosis in turn allows patients to be offered tailored information, appropriate care and support, and individualised treatment plans. These advances will provide improved access to clinical trials, which often exclude atypical phenotypes. Research into atypical Alzheiiner's disease has revealed previously unrecognised neuropathological heterogeneity across the Alzheimer's disease spectrum. Neuroimaging, genetic, biomarker, and basic science studies are providing key insights into the factors that might drive selective vulnerability of differing brain networks, with potential mechanistic implications for understanding typical late-onset Alzheimer's disease.

引用

页码：222 / 234

页数：13

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