Podocytes and the actin cytoskeleton as a feasible therapeutic target

被引：1
|
作者：
Sever, Sanja [1 ]
Gu, Changkyu [1 ]
机构：
[1] Massachusetts Gen Hosp, Div Nephrol, Charlestown, MA 02129 USA
来源：
PERIODICUM BIOLOGORUM | 2016年 / 118卷 / 04期
关键词：
Podocyte; Proteinuria; Chronic kidney disease; Actin cytoskeleton; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; UNILATERAL URETERAL OBSTRUCTION; PROTEINURIC KIDNEY-DISEASE; RHO KINASE INHIBITION; DYNAMIN OLIGOMERIZATION; GLOMERULAR INJURY; MUTATIONS; BIOLOGY; GTPASES; RAC1;
D O I：
10.18054/pb.v118i4.4576
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Podocyte injury is a hallmark of the glomerular disease, which is a direct cause of chronic kidney diseases. Importantly, podocyte injury is a consequence of the dysregulation of the actin cytoskeleton. In diverse animal models of proteinuric glomerular disease, recovering the integrity of the actin structure in podocytes resulted in beneficial effects. In this review, we focus on the premise of targeting the actin cytoskeleton as feasible therapeutics for treating chronic kidney diseases.
引用
收藏
页码：381 / 384
页数：4
相关论文
共 50 条
  • [31] Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes
    Martinez-Garcia, Cristina
    Izquierdo-Lahuerta, Adriana
    Vivas, Yurena
    Velasco, Ismael
    Yeo, Tet-Kin
    Chen, Sheldon
    Medina-Gomez, Gema
    PLOS ONE, 2015, 10 (11):
  • [32] Injury-induced actin cytoskeleton reorganization in podocytes revealed by super-resolution microscopy
    Suleiman, Hani Y.
    Roth, Robyn
    Jain, Sanjay
    Heuser, John E.
    Shaw, Andrey S.
    Miner, Jeffrey H.
    JCI INSIGHT, 2017, 2 (16)
  • [33] Plant polysome binding to the actin cytoskeleton as a target for physiological regulation
    Klyachko, NL
    Kulikova, AL
    Erokhina, MA
    CELL BIOLOGY INTERNATIONAL, 2003, 27 (03) : 217 - 218
  • [34] Actin cytoskeleton reorganization mediated by GAK, a cellular target of gefitinib
    Hiramoto, Masaki
    Takano, Naoharu
    Kazama, Hiromi
    Miyazawa, Keisuke
    CANCER SCIENCE, 2023, 114 : 2107 - 2107
  • [35] Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton
    Tonsawan, Pantipa
    Dylewski, James
    Lewis, Linda
    Blaine, Judith
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2019, 317 (05): : C1048 - C1060
  • [36] The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders
    Eira, Jessica
    Silva, Catarina Santos
    Sousa, Monica Mendes
    Liz, Marcia Almeida
    PROGRESS IN NEUROBIOLOGY, 2016, 141 : 61 - 82
  • [37] Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins
    Ares, IR
    Louzao, MC
    Vieytes, AR
    Yasumoto, T
    Botana, LA
    JOURNAL OF EXPERIMENTAL BIOLOGY, 2005, 208 (22): : 4345 - 4354
  • [38] Improving the specificity of drugs which target the actin cytoskeleton for cancer therapy
    Segueira, Vanessa B.
    Stehn, Justine R.
    Haass, Nikolas
    Bonello, Teresa
    Guven, Kim
    Desouza, Melissa
    Schevzov, Galina
    Kottyan, Gregg
    McCluskey, Adam
    Bischof, Leanne
    Palmer, Stephen
    Hardeman, Edna C.
    Allanson, Munif
    Reeve, Vivienne
    Weninger, Wolfgang
    Cripe, Timothy P.
    Gunning, Peter
    CANCER RESEARCH, 2012, 72
  • [39] The cortical actin cytoskeleton of lactotropes as an intracellular target for the control of prolactin secretion
    Carbajal, ME
    Vitale, ML
    ENDOCRINOLOGY, 1997, 138 (12) : 5374 - 5384
  • [40] STRUCTURAL PECULIARITIES OF THE CYTOSKELETON OF PODOCYTES OF THE VERTEBRATES
    ZAITSEV, VB
    GAMBARYAN, SP
    TSITOLOGIYA, 1986, 28 (09): : 926 - &
12345