Podocytes and the actin cytoskeleton as a feasible therapeutic target

被引：1
|
作者：
Sever, Sanja [1 ]
Gu, Changkyu [1 ]
机构：
[1] Massachusetts Gen Hosp, Div Nephrol, Charlestown, MA 02129 USA
来源：
PERIODICUM BIOLOGORUM | 2016年 / 118卷 / 04期
关键词：
Podocyte; Proteinuria; Chronic kidney disease; Actin cytoskeleton; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; UNILATERAL URETERAL OBSTRUCTION; PROTEINURIC KIDNEY-DISEASE; RHO KINASE INHIBITION; DYNAMIN OLIGOMERIZATION; GLOMERULAR INJURY; MUTATIONS; BIOLOGY; GTPASES; RAC1;
D O I：
10.18054/pb.v118i4.4576
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Podocyte injury is a hallmark of the glomerular disease, which is a direct cause of chronic kidney diseases. Importantly, podocyte injury is a consequence of the dysregulation of the actin cytoskeleton. In diverse animal models of proteinuric glomerular disease, recovering the integrity of the actin structure in podocytes resulted in beneficial effects. In this review, we focus on the premise of targeting the actin cytoskeleton as feasible therapeutics for treating chronic kidney diseases.
引用
收藏
页码：381 / 384
页数：4
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