Influence of past breast feeding on pattern and severity of presentation of juvenile idiopathic arthritis

被引：22

作者：

Hyrich, Kimme L. ^{[1
,2
]}

Baildam, Eileen ^{[3
]}

Pickford, Hannah ^{[1
]}

Chieng, Alice ^{[4
]}

Davidson, Joyce E. ^{[5
,6
]}

Foster, Helen ^{[7
,8
]}

Gardner-Medwin, Janet ^{[9
]}

Wedderburn, Lucy R. ^{[10
,11
,12
]}

Thomson, Wendy ^{[1
,2
]}

机构：

[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Arthrit Res UK Ctr Epidemiol, Ctr Musculoskeletal Res,Inst Inflammat & Repair, Room 2-800 Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England

[2] Cent Manchester NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Musculoskeletal Biomed Res Unit, Manchester, Lancs, England

[3] Alder Hey Childrens NHS Fdn Trust Hosp, Dept Rheumatol, Liverpool, Merseyside, England

[4] Cent Manchester Univ Hosp NHS Fdn Trust, Royal Manchester Childrens Hosp, Dept Rheumatol, Manchester, Lancs, England

[5] Greater Glasgow & Clyde Hlth Board, Royal Hosp Sick Children, Dept Rheumatol, Edinburgh, Midlothian, Scotland

[6] Royal Hosp Sick Children, Edinburgh EH9 1LF, Midlothian, Scotland

[7] Newcastle Univ, Dept Rheumatol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[8] Newcastle Hosp NHS Fdn Trust, Great North Childrens Hosp, Newcastle Upon Tyne, Tyne & Wear, England

[9] Univ Glasgow, Dept Rheumatol, Glasgow, Lanark, Scotland

[10] UCL, UCL Inst Child Hlth, Infect Immunol & Rheumatol Sect, London, England

[11] Great Ormond St Hosp NHS Fdn Trust, Dept Rheumatol, London, England

[12] UCL, Univ Coll London Hosp, Ctr Adolescent Rheumatol, London, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2016年 / 101卷 / 04期

关键词：

DISEASE; RISK;

D O I：

10.1136/archdischild-2014-308117

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This analysis aimed to study the influence of breast feeding on the pattern and severity of juvenile idiopathic arthritis (JIA) at presentation. The association between ever versus never breast feeding and disease severity at onset was compared in 923 children with JIA recruited to the UK Childhood Arthritis Prospective Study at first presentation to rheumatology. Fifty six per cent of children were ever breast fed (median 3.7 months). Breastfed children reported a lower median age at onset, a lower Childhood Health Assessment Questionnaire (CHAQ), a measure of disease severity, lower parent general evaluation scores and lower pain at presentation. There was a trend towards a higher proportion of breastfed children with rheumatoid factor-negative polyarthritis, but lesser enthesitis-related and psoriatic arthritis. There was a statistically significant inverse association between breast feeding and high CHAQ, even after adjusting for differences in socioeconomic status (adjusted OR 0.61 (95% CI 0.39 to 0.95)). Further work to understand the reasons behind these associations is required.

引用

页码：348 / 351

页数：4

共 11 条

[1] Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies [J].