Histological endpoints and oxidative stress transcriptional responses in the Mediterranean mussel Mytilus galloprovincialis exposed to realistic doses of salicylic acid

被引：21

作者：

Afsa, Sabrine ^{[1
,2
]}

De Marco, Giuseppe ^{[2
]}

Giannetto, Alessia ^{[2
]}

Parrino, Vincenzo ^{[2
]}

Cappello, Tiziana ^{[2
]}

ben Mansour, Hedi ^{[1
]}

Maisano, Maria ^{[2
]}

机构：

[1] Univ Monastir, Res Unit Anal & Proc Appl Environm APAE UR17ES32, Higher Inst Appl Sci & Technol Mandia, Monastir 5000, Tunisia

[2] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale F Stagno dAlcontres 31, I-98166 Messina, Italy

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2022年 / 92卷

关键词：

Pharmaceutically active compounds (PhACs); Mussel digestive gland; Cu-Zn superoxide dismutase; Mn superoxide dismutase; Catalase; Glutathione S-transferase; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CLAM RUDITAPES-PHILIPPINARUM; ENVIRONMENTAL RISK; PHARMACEUTICALS; IBUPROFEN; DICLOFENAC; INVERTEBRATES; CARBAMAZEPINE; EXPRESSION; BIOMARKERS;

D O I：

10.1016/j.etap.2022.103855

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Despite the availability of analytic data, little is known about the toxicity of salicylic acid (SA) on aquatic non target organisms. The present study aimed at evaluating the impact of SA through a short-term exposure of the Mediterranean mussel Mytilus galloprovincialis to five environmentally relevant concentrations of SA. A set of suitable biomarkers was applied at selected time-points on mussel digestive glands, including histological observations and expression of oxidative stress related genes. The obtained results showed a conspicuous hemocytic infiltration among mussel digestive tubules, as confirmed also by a flow cytometric approach that revealed an increase of halinocytes and granulocytes. Interestingly, a significant dose and time dependent decrease in the expression levels of oxidative stress related genes was found in mussels exposed to SA except for the glutathione Stransferase gene that was significantly up-regulated in a time-dependent manner confirming its important role against oxidant species and in the metabolism of pharmaceuticals.

引用

页数：10

共 93 条

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