Two convergent approaches to the synthesis of to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) by the lythgoe and the trost coupling reactions

被引：0

作者：

Maeyama, Junji ^{[1
]}

Hiyamizu, Hiroko

Takahashi, Keisuke

Ishihara, Jun

Hatakeyama, Susumi

Kubodera, Noboru

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan

[2] Chugai Pharmaceut Co Ltd, Chuo Ku, Tokyo 1038324, Japan

来源：

HETEROCYCLES | 2006年 / 70卷

关键词：

active vitamin D-3 analog; 1,25(OH)(2)D-3; ED-71; convergent synthesis;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two convergent syntheses of l alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (ED-71) by the Lythgoe coupling reaction between the A-ring phosphine oxide and the C/D-ring ketone and the Trost coupling reaction between the A-ring ene-yne and the C/D-ring bromomethylene are described.

引用

页码：295 / +

页数：14

共 20 条

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