Epigenetic regulations in mammalian spermatogenesis: RNA-m6A modification and beyond

被引：51
作者：
Gui, Yiqian [1 ]
Yuan, Shuiqiao [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Reprod Hlth, Wuhan 430030, Peoples R China
[2] Shenzhen Huazhong Univ Sci & Technol, Res Inst, Shenzhen 518057, Peoples R China
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2021年 / 78卷 / 11期
基金：
中国国家自然科学基金;
关键词：
m(6)A; RNA modification; Spermatogenesis; Sperm RNA; Epigenetic inheritance; MESSENGER-RNA METHYLATION; N-6-METHYLADENOSINE MODIFICATION; TRANSGENERATIONAL INHERITANCE; N6-METHYLADENOSINE RNA; SERTOLI-CELLS; CIRCULAR RNAS; YTH DOMAIN; EXPRESSION; SPERM; PROMOTES;
D O I：
10.1007/s00018-021-03823-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Emerging evidence shows that m(6)A, one of the most abundant RNA modifications in mammals, is involved in the entire process of spermatogenesis, including mitosis, meiosis, and spermiogenesis. "Writers" catalyze m(6)A formation on stage-specific transcripts during male germline development, while "erasers" remove m(6)A modification to maintain a balance between methylation and demethylation. The different functions of RNA-m(6)A transcripts depend on their recognition by "readers". m(6)A modification mediates RNA metabolism, including mRNA splicing, translation, and degradation, as well as the maturity and biosynthesis of non-coding RNAs. Sperm RNA profiles are easily affected by environmental exposure and can even be inherited for several generations, similar to epigenetic inheritance. Here, we review and summarize the critical role of m(6)A in different developmental stages of male germ cells, to understand of the mechanisms and epigenetic regulation of m(6)A modifications. In addition, we also outline and discuss the important role of non-coding RNAs in spermatogenesis and RNA modifications in epigenetic inheritance.
引用
收藏
页码：4893 / 4905
页数：13
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