Conjugated-Polymer-Based Nanoparticles with Efficient NIR-II Fluorescent, Photoacoustic and Photothermal Performance

被引：38

作者：

Miao, Yawei ^{[1
]}

Gu, Chuantao ^{[1
]}

Yu, Bing ^{[1
,4
]}

Zhu, Yaowei ^{[1
]}

Zou, Wentao ^{[1
]}

Shen, Youqing ^{[1
,2
,3
]}

Cong, Hailin ^{[1
,4
]}

机构：

[1] Qingdao Univ, Coll Mat Sci & Engn, Inst Biomed Mat & Engn, Qingdao 266071, Shandong, Peoples R China

[2] Zhejiang Univ, Coll Chem & Biol Engn, Ctr Bionanoengn, Minist Educ, Hangzhou 310027, Zhejiang, Peoples R China

[3] Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn, Minist Educ, Hangzhou 310027, Zhejiang, Peoples R China

[4] Qingdao Univ, Lab New Fiber Mat & Modern Text, Coll Chem & Chem Engn, Growing Base State Key Lab, Qingdao 266071, Shandong, Peoples R China

来源：

CHEMBIOCHEM | 2019年 / 20卷 / 21期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

conjugated polymers; imaging agents; nanoparticles; photothermal conversion; second near-infrared; QUANTUM DOTS; PROBES; WINDOW; DYE; FLUOROPHORES; OXYGEN;

D O I：

10.1002/cbic.201900309

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluorescence imaging (FI) and photoacoustic imaging (PA) play important roles in the real-time assessment of cell-based therapies. However, the limitations of conventional organic fluorescence contrast agents and the narrow range of the emission wavelength in the first near-infrared (NIR-I) window (750-900 nm) hamper applications of fluorescence imaging in living subjects. Herein, we report the design and synthesis of a short-wave infrared FI contrast agent and PA contrast agent based on a conjugated polymer-poly{2,5-bis[(5-thiophen-2-yl)methylene]-3,6-bis(2-octyldodecyl)-2,5-dihydropyrazine}-and its use to construct multifunctional nanoparticles to simplify photothermal therapy.

引用

页码：2793 / 2799

页数：7

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