Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis

被引：39
作者：
Nasu, Kaei [1 ]
Yuge, Akitoshi [1 ]
Tsuno, Akitoshi [1 ]
Narahara, Hisashi [1 ]
机构：
[1] Oita Univ, Dept Obstet & Gynecol, Fac Med, Yufu, Oita 8795593, Japan
来源：
FERTILITY AND STERILITY | 2009年 / 92卷 / 06期
基金：
日本学术振兴会;
关键词：
POSSIBLE MECHANISM; PERITONEAL ENDOMETRIOSIS; RHO-GTPASES; STATINS; COLLAGEN; GROWTH; PATHOGENESIS;
D O I：
10.1016/j.fertnstert.2009.06.055
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is considered to be a promising agent for the treatment of endometriosis-associated fibrosis, which is among the major pathologies caused by endometriosis. (Fertil Steril (R) 2009;92:2097-9. (C)2009 by American Society for Reproductive Medicine.)
引用
收藏
页码：2097 / 2099
页数：3
相关论文
共 23 条
  • [11] Regulation of proliferation, motility, and contractility of human endometrial stromal cells by platelet-derived growth factor
    Matsumoto, H
    Nasu, K
    Nishida, M
    Ito, H
    Bing, S
    Miyakawa, I
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (06) : 3560 - 3567
  • [12] Fibrogenesis in peritoneal endometriosis - A semi-quantitative analysis of type-I collagen
    Matsuzaki, S
    Canis, M
    Darcha, C
    Dechelotte, P
    Pouly, JL
    Bruhat, MA
    [J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1999, 47 (03) : 197 - 199
  • [13] Statins -: a cure-all for the brain?
    Menge, T
    Hartung, HP
    Stüve, O
    [J]. NATURE REVIEWS NEUROSCIENCE, 2005, 6 (04) : 325 - 331
  • [14] MOLGAARD J, 1988, EUR HEART J, V9, P541
  • [15] NASU K, 2008, RES ADV HUM REPROD, V1, P1
  • [16] Endometriotic cells are resistant to interferon-γ-induced cell growth inhibition and apoptosis:: a possible mechanism involved in the pathogenesis of endometriosis
    Nishida, M
    Nasu, K
    Ueda, T
    Fukuda, J
    Takai, N
    Miyakawa, I
    [J]. MOLECULAR HUMAN REPRODUCTION, 2005, 11 (01) : 29 - 34
  • [17] Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells: A possible mechanism for the altered immunological functions in endometriosis
    Nishida, M
    Nasu, K
    Fukuda, J
    Kawano, Y
    Narahara, H
    Miyakawa, I
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (10) : 5094 - 5100
  • [18] Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities
    Nisolle, M
    Donnez, J
    [J]. FERTILITY AND STERILITY, 1997, 68 (04) : 585 - 596
  • [19] Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability
    Piotrowski, Piotr C.
    Kwintkiewicz, Jakub
    Rzepczynska, Izabela J.
    Seval, Yasemin
    Cakmak, Hakan
    Arici, Aydin
    Duleba, Antoni J.
    [J]. BIOLOGY OF REPRODUCTION, 2006, 75 (01) : 107 - 111
  • [20] STOVALL DW, 1992, FERTIL STERIL, V57, P984
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