Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis

被引：39
作者：
Nasu, Kaei [1 ]
Yuge, Akitoshi [1 ]
Tsuno, Akitoshi [1 ]
Narahara, Hisashi [1 ]
机构：
[1] Oita Univ, Dept Obstet & Gynecol, Fac Med, Yufu, Oita 8795593, Japan
来源：
FERTILITY AND STERILITY | 2009年 / 92卷 / 06期
基金：
日本学术振兴会;
关键词：
POSSIBLE MECHANISM; PERITONEAL ENDOMETRIOSIS; RHO-GTPASES; STATINS; COLLAGEN; GROWTH; PATHOGENESIS;
D O I：
10.1016/j.fertnstert.2009.06.055
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is considered to be a promising agent for the treatment of endometriosis-associated fibrosis, which is among the major pathologies caused by endometriosis. (Fertil Steril (R) 2009;92:2097-9. (C)2009 by American Society for Reproductive Medicine.)
引用
收藏
页码：2097 / 2099
页数：3
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