Experimental study of the inclusion of triclosan in hydroxypropyl-β-cyclodextrins

被引：11
|
作者：
Lavecchia, Roberto [1 ]
Zuorro, Antonio [1 ]
机构：
[1] Univ Roma La Sapienza, Dept Chem Engn Mat & Environm, I-00184 Rome, Italy
来源：
ICHEAP-9: 9TH INTERNATIONAL CONFERENCE ON CHEMICAL AND PROCESS ENGINEERING, PTS 1-3 | 2009年 / 17卷
关键词：
D O I：
10.3303/CET0917181
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Triclosan, an antimicrobial agent with an extremely low water solubility, was included in the hydrophobic cavity of hydroxypropyl-beta-cyclodextrins. Complex formation was evaluated by the Higuchi-Connors phase-solubility method and by UV difference Spectrophotometry. The results obtained by both methods suggest that an inclusion complex of 1 : 1 stoichiometry is formed. The estimated association constant was close to 500 M-1, indicating it considerably high stability. As a result of complexation, triclosan solubility in aqueous ethanol (10% v/v) showed an almost 70-fold increase.
引用
收藏
页码：1083 / 1088
页数：6
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