The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels

被引：77
作者：
Galione, Antony [1 ]
Evans, A. Mark [2 ]
Ma, Jianjie [3 ]
Parrington, John [1 ]
Arredouani, Abdelilah [1 ]
Cheng, Xiaotong [1 ]
Zhu, Michael X. [4 ]
机构：
[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
[2] Univ Edinburgh, Coll Med & Vet Med, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland
[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, Piscataway, NJ 08854 USA
[4] Ohio State Univ, Biochem & Ctr Mol Neurobiol, Dept Neurosci, Columbus, OH 43210 USA
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2009年 / 458卷 / 05期
基金：
英国惠康基金; 美国国家卫生研究院;
关键词：
Inositol 1,4,5-trisphosphate; Pancreatic beta-cell; Endothelin; Cholecystokinin; Ca2+-induced Ca2+ release; Ion channel; Ca2+ mobilisation; Ca2+ stores; Calcium signalling; Calcium transient; ADENINE-DINUCLEOTIDE PHOSPHATE; CYCLIC ADP-RIBOSE; SEA-URCHIN EGG; PANCREATIC-ACINAR-CELLS; ARTERIAL SMOOTH-MUSCLE; MOBILIZES CA2+; INOSITOL TRISPHOSPHATE; PYRIDINE-NUCLEOTIDE; CALCIUM-RELEASE; TRIGGER ZONE;
D O I：
10.1007/s00424-009-0682-y
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca2+ mobilisation. In addition, we describe how TPCs may also trigger further Ca2+ release by coupling to the endoplasmic reticular stores through activation of IP3 receptors and ryanodine receptors.
引用
收藏
页码：869 / 876
页数：8
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