The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels

被引：77

作者：

Galione, Antony ^{[1
]}

Evans, A. Mark ^{[2
]}

Ma, Jianjie ^{[3
]}

Parrington, John ^{[1
]}

Arredouani, Abdelilah ^{[1
]}

Cheng, Xiaotong ^{[1
]}

Zhu, Michael X. ^{[4
]}

机构：

[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

[2] Univ Edinburgh, Coll Med & Vet Med, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, Piscataway, NJ 08854 USA

[4] Ohio State Univ, Biochem & Ctr Mol Neurobiol, Dept Neurosci, Columbus, OH 43210 USA

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2009年 / 458卷 / 05期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

Inositol 1,4,5-trisphosphate; Pancreatic beta-cell; Endothelin; Cholecystokinin; Ca2+-induced Ca2+ release; Ion channel; Ca2+ mobilisation; Ca2+ stores; Calcium signalling; Calcium transient; ADENINE-DINUCLEOTIDE PHOSPHATE; CYCLIC ADP-RIBOSE; SEA-URCHIN EGG; PANCREATIC-ACINAR-CELLS; ARTERIAL SMOOTH-MUSCLE; MOBILIZES CA2+; INOSITOL TRISPHOSPHATE; PYRIDINE-NUCLEOTIDE; CALCIUM-RELEASE; TRIGGER ZONE;

D O I：

10.1007/s00424-009-0682-y

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca2+ mobilisation. In addition, we describe how TPCs may also trigger further Ca2+ release by coupling to the endoplasmic reticular stores through activation of IP3 receptors and ryanodine receptors.

引用

页码：869 / 876

页数：8

共 50 条

[1] The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels
Antony Galione
A. Mark Evans
Jianjie Ma
John Parrington
Abdelilah Arredouani
Xiaotong Cheng
Michael X. Zhu
Pflügers Archiv - European Journal of Physiology, 2009, 458 : 869 - 876
[2] Domain assembly of NAADP-gated two-pore channels
Churamani, Dev
Hooper, Robert
Brailoiu, Eugen
Patel, Sandip
BIOCHEMICAL JOURNAL, 2012, 441 : 317 - 323
[3] Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?
Patel, Sandip
Brailoiu, Eugen
BIOCHEMICAL SOCIETY TRANSACTIONS, 2012, 40 : 153 - 157
[4] Ca2+ signals, NAADP and two-pore channels: role in cellular differentiation
Parrington, J.
Tunn, R.
ACTA PHYSIOLOGICA, 2014, 211 (02) : 285 - 296
[5] TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP
Zhu, Michael X.
Ma, Jianjie
Parrington, John
Galione, Antony
Evans, A. Mark
FEBS LETTERS, 2010, 584 (10) : 1966 - 1974
[6] Diversity of two-pore channels and the accessory NAADP receptors in intracellular Ca2+ signaling
Shah, Kunal R.
Guan, Xin
Yan, Jiusheng
CELL CALCIUM, 2022, 104
[7] An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+ Signals
Brailoiu, Eugen
Rahman, Taufiq
Churamani, Dev
Prole, David L.
Brailoiu, G. Cristina
Hooper, Robert
Taylor, Colin W.
Patel, Sandip
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (49) : 38511 - 38516
[8] Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions
Feijoo-Bandin, Sandra
Garcia-Vence, Maria
Garcia-Rua, Vanessa
Rosello-Lleti, Esther
Portoles, Manuel
Rivera, Miguel
Ramon Gonzalez-Juanatey, Jose
Lago, Francisca
CHANNELS, 2017, 11 (01) : 20 - 33
[9] Two-pore channels (TPCs): Current controversies
Morgan, Anthony J.
Galione, Antony
BIOESSAYS, 2014, 36 (02) : 173 - 183
[10] Ca2+ and Na+ Release Measurements from Two-Pore Channels residing in their natural endolysosomal Membrane Environments
Mallmann, R. T.
Mantuano, M. C. Gonzalez
Klugbauer, N.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2024, 397 : S46 - S46

← 1 2 3 4 5 →