Wnt-7a is upregulated by norethisterone in human endometrial epithelial cells: a possible mechanism by which progestogens reduce the risk of estrogen-induced endometrial neoplasia

被引：11

作者：

Oehler, MK

MacKenzie, IZ

Wallwiener, D

Bicknell, R

Rees, MCP ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England

[2] Univ Oxford, John Radcliffe Hosp, Imperial Canc Res Fund, Mol Angiogenesis Lab,Inst Mol Med, Oxford OX3 9DU, England

[3] Univ Tubingen, Dept Obstet & Gynaecol, D-72074 Tubingen, Germany

来源：

CANCER LETTERS | 2002年 / 186卷 / 01期

关键词：

hormone replacement therapy; endometrial cancer; progestogens; norethisterone acetate; gene expression array; Wnt-7a;

D O I：

10.1016/S0304-3835(02)00259-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Progestogens are added to oestrogen in hormone replacement therapy regimens to reduce the risk of endometrial cancer. We have performed in vitro studies analysing gene expression of isolated normal endometrial epithelia cells (NEE) treated with estradiol and the progestogen norethisterone acetate (NETA). We report here for the first time upregulation of the Wnt-7a gene by NETA in estrogen treated NEE. Wnt genes are a large family of developmental genes associated with cellular responses such as oncogenesis. We therefore suggest that upregulation of Wnt-7a may be associated with the antineoplastic effects of progestogens on the endometrium. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：75 / 81

页数：7

共 26 条

[1] Expression and hormone regulation of Wnt2,3,4,5a,7a,7b and 10b in normal human endometrium and endometrial carcinoma [J].