Prognostic value of FGF23 among patients with end-stage renal disease: a systematic review and meta-analysis

被引：16

作者：

Yang, Hongliu ^{[1
]}

Luo, Han ^{[2
]}

Tang, Xi ^{[1
]}

Zeng, Xiaoxi ^{[1
]}

Yu, Yang ^{[1
]}

Ma, Liang ^{[1
]}

Fu, Ping ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, West China Med Sch, Div Nephrol,Kidney Res Inst, Chengdu 610064, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, West China Med Sch, Div Thyroid Surg, Chengdu 610064, Sichuan, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 05期

关键词：

dialysis; end-stage renal disease; FGF23; mortality; FIBROBLAST GROWTH FACTOR-23; CHRONIC KIDNEY-DISEASE; LEFT-VENTRICULAR HYPERTROPHY; HEMODIALYSIS-PATIENTS; CARDIOVASCULAR-DISEASE; DIALYSIS PATIENTS; SECONDARY HYPERPARATHYROIDISM; PERITONEAL-DIALYSIS; PARATHYROID-HORMONE; MORTALITY;

D O I：

10.2217/bmm.16.11

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aims: Prognostic value of FGF23 in end-stage renal disease (ESRD) patients is controversial. A systematic review was conducted to quantify the association between elevated FGF23 and overall mortality among ESRD patients. Methods: MEDLINE, EMBASE, PubMed and reference lists were searched. Quality of the included studies was evaluated using Newcastle-Ottawa Scale checklist. Pooled effects were calculated as hazard ratio using fixed-effect models, and chi-square test was used for heterogeneity testing. Results: Seven studies (1406 patients) were included. Patients were at mean age of 62.3. Mean follow-up was 29.4 months. From the pooled analysis, elevated FGF23 was significantly associated with increased all-cause mortality (hazard ratio: 1.53; 95% CI: 1.05-2.25). p-value for heterogeneity was 0.10, I-2 = 48%. Conclusions: ESRD patients with elevated FGF23 concentration have higher risk of death.

引用

页码：547 / 556

页数：10

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