Differential susceptibility of several drug-resistant strains of herpes simplex virus type 2 to various antiviral compounds

被引：16
作者：
Andrei, G
Snoeck, R
DeClercq, E
机构：
来源：
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1997年 / 8卷 / 05期
关键词：
herpes simplex virus; resistance; acyclic nucleoside phosphonates; acyclovir; cidofovir;
D O I：
10.1177/095632029700800509
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Drugs-resistant herpes simplex virus type 2 (HSV-2) strains were obtained under the selective pressure of acyclovir, ganciclovir, brivudin, foscarnet, 2-phosphonylmethoxyethyl (PME) derivatives of adenine (PMEA) and 2,6-diaminopurine (PMEDAP), and 3-hydroxy-2-phosphonylmethoxypropyl (HPMP) derivatives of adenine (HPMPA) and cytosine (HPMPC; cidofovir). A significant degree of cross-resistance between HPMPC and HPMPA on the one hand, and between PMEA, PMEDAP and foscarnet on the other, was noted, suggesting a different mode of interaction of the PME and HPMP derivatives at the DNA polymerase level. The results described here with HSV-2 agree with the published results for HSV-1 and human cytomegalovirus.
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页码：457 / 461
页数：5
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