Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility

被引：34

作者：

Diamond, Michael P. ^{[1
,15
]}

Legro, Richard S. ^{[2
]}

Coutifaris, Christos ^{[3
]}

Alvero, Ruben ^{[4
]}

Robinson, Randal D. ^{[5
]}

Casson, Peter A. ^{[6
]}

Christman, Gregory M. ^{[7
]}

Huang, Hao ^{[18
]}

Hansen, Karl R. ^{[8
]}

Baker, Valerie ^{[9
]}

Usadi, Rebecca ^{[10
]}

Seungdamrong, Aimee ^{[11
]}

Bates, G. Wright ^{[12
]}

Rosen, R. Mitchell ^{[13
]}

Schlaff, William ^{[4
]}

Haisenleder, Daniel ^{[14
]}

Krawetz, Stephen A. ^{[15
]}

Barnhart, Kurt ^{[3
]}

Trussell, J. C. ^{[16
]}

Santoro, Nanette ^{[4
]}

Eisenberg, Esther ^{[17
]}

Zhang, Heping ^{[18
]}

机构：

[1] Georgia Regents Univ, Dept Obstet & Gynecol, Augusta, GA 30912 USA

[2] Penn State Univ, Dept Obstet & Gynecol, Hershey, PA USA

[3] Univ Penn, Sch Med, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA

[4] Univ Colorado, Dept Obstet & Gynecol, Denver, CO 80202 USA

[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, San Antonio, TX 78229 USA

[6] Univ Vermont, Dept Obstet & Gynecol, Burlington, VT USA

[7] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA

[8] Univ Oklahoma, Coll Med, Dept Obstet & Gynecol, Oklahoma City, OK 73190 USA

[9] Stanford Univ, Med Ctr, Stanford, CA 94305 USA

[10] Carolinas Med Ctr, Charlotte, NC 28203 USA

[11] Rutgers New Jersey Med Sch, Newark, NJ USA

[12] Univ Alabama Birmingham, Birmingham, AL USA

[13] Univ Calif San Francisco, Dept Reprod Endocrinol & Infertil, San Francisco, CA 94143 USA

[14] Univ Virginia, Ctr Res Reprod, Ligand Core Lab, Charlottesville, VA USA

[15] Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI 48202 USA

[16] Upstate Univ Hosp, Syracuse, NY USA

[17] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Fertil & Infertil Branch, Rockville, MD USA

[18] Yale Univ, Sch Publ Hlth, Dept Biostat, New Haven, CT USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2017年 / 217卷 / 02期

基金：

美国国家卫生研究院;

关键词：

female sexual dysfunction; infertility; polycystic ovary syndrome; unexplained infertility; SURGICALLY MENOPAUSAL WOMEN; MULTIPLE INTRAUTERINE GESTATIONS; BASE-LINE CHARACTERISTICS; STIMULATION AMIGOS TRIAL; QUALITY-OF-LIFE; TESTOSTERONE TREATMENT; DESIRE DISORDER; POSTMENOPAUSAL WOMEN; UNITED-STATES; DYSFUNCTION;

D O I：

10.1016/j.ajog.2017.04.034

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

BACKGROUND: While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed. OBJECTIVE: The objective of the study was to determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. STUDY DESIGN: A secondary data analysis was performed on 2 of Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Networks clinical trials: Pregnancy in Polycystic Ovary Syndrome Study II and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Both protocols assessed female sexual function using the Female Sexual Function Inventory and the Female Sexual Distress Scale. RESULTS: Women with polycystic ovary syndrome had higher weight and body mass index than women with unexplained infertility (each P < .001), greater phenotypic (Ferriman-Gallwey hirsutism score, sebum score, and acne score; each P < .001), and hormonal (testosterone, free testosterone, and dehydroepiandrosterone; each P < .001) evidence of androgen excess. Sexual function scores, as assessed by the Female Sexual Function Inventory, were nearly identical. The Female Sexual Distress Scale total score was higher in women with polycystic ovary syndrome. The mean Female Sexual Function Inventory total score increased slightly as the free androgen index increased, mainly as a result of the desire subscore. This association was more pronounced in the women with unexplained infertility. CONCLUSION: Reproductive-age women with infertility associated with polycystic ovary syndrome and unexplained infertility, despite phenotypic and biochemical differences in androgenic manifestations, do not manifest clinically significant differences in sexual function.

引用

页码：191.e1 / 191.e19

页数：19

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