Structurally diverse arene-fused ten-membered lactams accessed via hydrolytic imidazoline ring expansion

被引：29

作者：

Sapegin, Alexander ^{[1
]}

Osipyan, Angelina ^{[1
]}

Krasavin, Mikhail ^{[1
]}

机构：

[1] St Petersburg State Univ, Inst Chem, 26 Univ Skii Prospekt, Peterhof 198504, Russia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 14期

基金：

俄罗斯科学基金会;

关键词：

ORIENTED SYNTHESIS; DISCOVERY; STRATEGY; 2-IMIDAZOLINES; INHIBITORS; ARYLATION; PANEL;

D O I：

10.1039/c7ob00535k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Imidazoline-fused [1,4] oxazepines (prepared in two simple steps from methyl 2-hydroxyaroates, ethylene diamine and bis- electrophilic aromatics) undergo a facile, good-yielding hydrolytic imidazoline ring expansion (HIRE) upon N-alkylation and treatment with aqueous K2CO3. The resulting arene-fused ten-membered lactams significantly add to the contemporary arsenal of smallmolecule scaffolds where medium-sized ring systems are severely underrepresented.

引用

页码：2906 / 2909

页数：4

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