Outpatient vaginal administration of the nitric oxide donor isosorbide mononitrate for cervical ripening and labor induction postterm:: a randomized controlled study

被引:38
作者
Bullarbo, Maria [1 ]
Orrskog, Monica Eriksson
Andersch, Bjorn
Granstrom, Lena
Norstrom, Anders
Ekerhovd, Erling
机构
[1] Sahlgrens Univ Hosp, Dept Obstet & Gynecol, S-41345 Gothenburg, Sweden
[2] Boras Hosp, Dept Obstet & Gynecol, Boras, Sweden
关键词
cervical ripening; induction of labor; isosorbide mononitrate; nitric oxide;
D O I
10.1016/j.ajog.2006.08.034
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
A double-blind, randomized, controlled study of 200 women at 2 Swedish hospitals showed that vaginal administration of the nitric oxide donor isosorbide mononitrate induces effective cervical ripening and onset of labor in women postterm.
引用
收藏
页码:50 / 52
页数:3
相关论文
共 23 条
[1]  
Shea K.M., Wilcox A.J., Little R.E., Postterm delivery: a challenge for epidemiologic research, Epidemiology, 9, pp. 199-204, (1998)
[2]  
Campbell M.K., Ostbye T., Irgens L.M., Post-term birth: risk factors and outcomes in a 10-year cohort of Norwegian births, Obstet Gynecol, 89, pp. 543-548, (1997)
[3]  
Olesen A.W., Westergaard J.G., Olsen J., Perinatal and maternal complications related to postterm delivery: a national register-based study, 1978-1993, Am J Obstet Gynecol, 189, pp. 222-227, (2003)
[4]  
Keirse M., Any prostaglandin/any route for cervical ripening, (1995)
[5]  
Chwalisz K., Garfield R.E., Nitric oxide as the final mediator of cervical ripening, Hum Reprod, 13, pp. 245-252, (1998)
[6]  
Thomson A.J., Lunan C.B., Ledingham M., Howat R.C., Cameron I.T., Greer I.A., Et al., Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy, Lancet, 352, pp. 1093-1096, (1998)
[7]  
Chanrachakul B., Herabutya Y., Punyavachira P., Potential efficacy of nitric oxide for cervical ripening in pregnancy at term, Int J Gynecol Obstet, 71, pp. 217-219, (2000)
[8]  
Facchinetti F., Piccinini F., Volpe A., Chemical ripening of the cervix with intracervical application of sodium nitroprusside: a randomized controlled study, Hum Reprod, 15, pp. 2224-2227, (2000)
[9]  
Nicoll A.E., Mackenzie F., Greer I.A., Norman J.E., Vaginal application of the nitric oxide donor isosorbide mononitrate for preinduction cervical ripening: a randomized controlled trial to determine effects on maternal and fetal hemodynamics, Am J Obstet Gynecol, 184, pp. 958-964, (2001)
[10]  
Ekerhovd E., Bullarbo M., Andersch B., Norstrom A., Vaginal administration of the nitric oxide donor isosorbide mononitrate for cervical ripening at term: a randomized controlled study, Am J Obstet Gynecol, 189, pp. 1692-1697, (2003)