Ruthenium(II)-Catalyzed C-H Oxygenations of Reusable Sulfoximine Benzamides

被引：88

作者：

Raghuvanshi, Keshav ^{[1
]}

Zell, Daniel ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Georg August Univ Gottingen, Inst Organ & Biomolekulare Chem, Tammannstrasse 2, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 06期

基金：

欧洲研究理事会;

关键词：

ORTHO-BENZOXYLATION; DIRECTING GROUPS; BOND ACTIVATION; RUTHENIUM; ARENES; FUNCTIONALIZATION; HYDROXYLATION; HYDROARYLATION; (HETERO)ARENES; ACYLOXYLATION;

D O I：

10.1021/acs.orglett.6b03898

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-H oxygenations of synthetically meaningful sulfoximine benzamides were accomplished by a versatile ruthenium catalysis regime. The ruthenium(II) catalyst was characterized by excellent mono- and chemoselectivity as well as positional selectivity via facile base-assisted intramolecular electrophilic substitution-type (BIES) C-H activation. The synthetic utility of the approach was reflected by high functional group tolerance and sulfoximine removal in a traceless fashion.

引用

页码：1278 / 1281

页数：4

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