New 3D stratified Si-Ca-P porous scaffolds obtained by sol-gel and polymer replica method: Microstructural, mineralogical and chemical characterization

被引：30

作者：

Ros-Tarraga, Patricia ^{[1
]}

Murciano, Angel ^{[2
]}

Mazon, Patricia ^{[2
]}

Gehrke, Sergio A. ^{[3
]}

De Aza, Piedad N. ^{[1
]}

机构：

[1] Univ Miguel Hernandez, Inst Bioingn, Avda Ferrocarril S-N Elche, Alicante 03202, Spain

[2] Univ Miguel Hernandez, Dept Mat Opt & Tecnol Elect, Avda Univ S-N, Alicante 03202, Spain

[3] Biotecnos Res Ctr, Rua Dr Bonazo 57, BR-97015001 Santa Maria, RS, Brazil

来源：

CERAMICS INTERNATIONAL | 2017年 / 43卷 / 08期

关键词：

Sol-gel; Tissue engineering; Polymer sponge replica; TRICALCIUM PHOSPHATE; CERAMIC SCAFFOLDS; OSTEOCONDUCTIVE PROPERTIES; GLASS-CERAMICS; BONE; SPECTRA; BIOMATERIALS; SPECTROSCOPY; APATITE;

D O I：

10.1016/j.ceramint.2017.02.081

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The aim of this research was to develop and characterize a novel stratified porous scaffold for future uses in bone tissue engineering. In this study, a calcium silicophosphate porous scaffold, with nominal composition 29.32 wt % SiO2 - 67.8 wt% CaO - 2.88 wt% P2O5, was produced using the sol-gel and polymer replication methods. Polyurethane sponges were used as templates which were impregnated with a homogeneous sol solution and sintered at 950 degrees C and 1400 degrees C during 8 h. The characteristics of the 3D stratified porous scaffolds were investigated by Scanning Electron Microscopy, X-Ray Diffraction, Fourier Transform Infrared Spectrometry, Diametric Compression of Discs Test and Hg porosimetry techniques. The result showed highly porous stratified calcium silicophosphate scaffolds with micro and macropores interconnected. Also, the material has a diametrical strength dependent on the number of layers of the stratified scaffolds and the sintering temperature.

引用

页码：6548 / 6553

页数：6

共 34 条

[1] Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair [J].

Agarwal, Rachit ;

Garcia, Andres J. .

ADVANCED DRUG DELIVERY REVIEWS, 2015, 94 :53-62

[2] Structural study of sol-gel silicate glasses by IR and Raman spectroscopies [J].

Aguiar, H. ;

Serra, J. ;

Gonzalez, P. ;

Leon, B. .

JOURNAL OF NON-CRYSTALLINE SOLIDS, 2009, 355 (08) :475-480

[3]

[Anonymous], 2007, ADV TECHNICAL CERA 5

[4] α-Tricalcium phosphate: Synthesis, properties and biomedical applications [J].

Carrodeguas, R. G. ;

De Aza, S. .

ACTA BIOMATERIALIA, 2011, 7 (10) :3536-3546

[5] New approach to the β→α polymorphic transformation in magnesium-substituted tricalcium phosphate and its practical implications [J].

Carrodeguas, Raul Garcia ;

De Aza, Antonio H. ;

Turrillas, Xavier ;

Pena, Pilar ;

De Aza, Salvador .

JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2008, 91 (04) :1281-1286

[6] 45S5 Bioglass®-derived glass-ceramic scaffolds for bone tissue engineering [J].

Chen, QZZ ;

Thompson, ID ;

Boccaccini, AR .

BIOMATERIALS, 2006, 27 (11) :2414-2425

[7] RETRACTED: Bone neoformation of a novel porous resorbable Si-Ca-P-based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study (Retracted article. See vol. 29, pg. 537, 2018) [J].

De Aza, Piedad N. ;

Mate-Sanchez de Val, Jose E. ;

Baudin, Carmen ;

Perez Albacete-Martinez, Carlos ;

Armijo Salto, Antonio ;

Calvo-Guirado, Jose L. .

CLINICAL ORAL IMPLANTS RESEARCH, 2016, 27 (11) :1368-1375

[8] Design and characterization of calcium phosphate ceramic scaffolds for bone tissue engineering [J].

Denry, Isabelle ;

Kuhn, Liisa T. .

DENTAL MATERIALS, 2016, 32 (01) :43-53

[9] Current Progress in Bioactive Ceramic Scaffolds for Bone Repair and Regeneration [J].

Gao, Chengde ;

Deng, Youwen ;

Feng, Pei ;

Mao, Zhongzheng ;

Li, Pengjian ;

Yang, Bo ;

Deng, Junjie ;

Cao, Yiyuan ;

Shuai, Cijun ;

Peng, Shuping .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (03) :4714-4732

[10] Effect of Mg and Si co-substitution on microstructure and strength of tricalcium phosphate ceramics [J].

Garcia-Paez, Ismael H. ;

Garcia Carrodeguas, Raul ;

De Aza, Antonio H. ;

Baudin, Carmen ;

Pena, Pilar .

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2014, 30 :1-15

← 1 2 3 4 →