Therapeutic Delivery to Central Nervous System

被引：11
作者：
Kunigelis, Katherine E. [1 ]
Vogelbaum, Michael A. [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Neurooncol, Neurooncol Program, 12902 USF Magnolia Dr, Tampa, FL 33612 USA
来源：
NEUROSURGERY CLINICS OF NORTH AMERICA | 2021年 / 32卷 / 02期
关键词：
Glioblastoma; Clinical trials; Blood-brain barrier; Blood-brain-tumor barrier; Convection-enhanced delivery; BLOOD-BRAIN-BARRIER; THERMAL THERAPY; DRUG-DELIVERY; PHASE-II; GLIOMA; GLIOBLASTOMA; TUMOR; NANOPARTICLES; TEMOZOLOMIDE; CHALLENGES;
D O I：
10.1016/j.nec.2020.12.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
? Direct administration of agents to bypass the BBB include implantable controlled-release polymer systems, intracavitary drug delivery, direct injection of viral vectors, and convection-enhanced delivery (CED). ? CED uses direct pump-mediated continuous infusion into the tumor bed or tumor adjacent brain, circumventing the BBB. This approach has shown promising results with infusion of immunotoxins,
引用
收藏
页码：291 / 303
页数：13
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