Clinical and Genetic Characteristics of Mexican Huntington's Disease Patients

被引：35

作者：

Elisa Alonso, Maria ^{[1
]}

Ochoa, Adriana ^{[1
]}

Boll, Marie-Catherine ^{[2
]}

Sosa, Ana Luisa ^{[3
]}

Yescas, Petra ^{[1
]}

Lopez, Marisol ^{[4
]}

Macias, Rosario ^{[1
]}

Familiar, Itziar ^{[5
]}

Rasmussen, Astrid ^{[6
]}

机构：

[1] Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Dept Neurogenet & Mol Biol, Mexico City 14269, DF, Mexico

[2] Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Div Neurol, Mexico City 14269, DF, Mexico

[3] Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Clin Behav & Cognit, Mexico City 14269, DF, Mexico

[4] Univ Autonoma Metropolitana Xochimilco, Dept Biol Syst, Mexico City, DF, Mexico

[5] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA

[6] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK 73190 USA

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 13期

关键词：

Huntington's disease; CAG repeat; Latin-American population; Mexican population; ONSET; MUTATION;

D O I：

10.1002/mds.22737

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the characteristics of 691 Mexican patients with Huntington's disease (HD). These patients, representing 401 families, constitute the largest series of Mexican HD cases as yet described in the literature. We found the clinical characteristics of these patients to be similar to those of other populations, but we observed a higher frequency of infantile cases, a shorter disease duration and a lower suicide rate. In 626 cases, for which molecular analyses were available, CAG-trinucleotide expansion size ranged from 37-106 repeats. The large number of CAG repeats (19.04 +/- 3.02) in normal alleles and the presence of new mutations suggest that the overall prevalence of HD in the Mexican population could be expected to be within range of, or higher than, that reported for Europeans. (C) 2009 Movement Disorder Society

引用

页码：2012 / 2015

页数：4

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