Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis

被引：8

作者：

Petrenko, V. A. ^{[1
]}

Pakharukova, M. Yu. ^{[1
,2
]}

Kovner, A. V. ^{[1
]}

L'vova, M. N. ^{[1
]}

Lyakhovich, V. V. ^{[2
]}

Mordvinov, V. A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Div, Fed Res Ctr, Inst Cytol & Genet, Novosibirsk, Russia

[2] Res Inst Mol Biol & Biophys, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 162卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

opisthorchiasis; excretory-secretory product; active oxygen species; thioredoxin peroxidase; cat liver fluke Opisthorchis felineus; ANTIOXIDANT ENZYME;

D O I：

10.1007/s10517-017-3710-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mechanisms of thioredoxin peroxidase secretion by Opisthorchis felineus were studied in vivo and in vitro. Specific antibodies were obtained and used for western blotting and immunohistochemical detection in Syrian hamster model of opisthorchiasis. Secreted thioredoxin peroxidase protein was accumulated in the worm incubation medium under conditions of oxidative stress and in bile duct cells of hamsters with chronic opisthorchiasis.

引用

页码：773 / 776

页数：4

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