Stereotactic Transcranial Focused Ultrasound Targeting System for Murine Brain Models

被引：7

作者：

Choi, Sang Won ^{[1
]}

Gerhardson, Tyler, I ^{[1
]}

Duclos, Sarah E. ^{[1
]}

Surowiec, Rachel K. ^{[2
,3
]}

Scheven, Ulrich M. ^{[4
]}

Galban, Stefanie ^{[2
,3
]}

Lee, Fred T., Jr. ^{[5
]}

Greve, Joan M. ^{[1
]}

Balter, James M. ^{[6
]}

Hall, Timothy L. ^{[1
]}

Xu, Zhen ^{[1
]}

机构：

[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Ctr Mol Imaging, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA

[5] Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA

[6] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

来源：

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL | 2021年 / 68卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Accuracy; brain tumors; focused ultrasound (FUS); glioblastoma; histotripsy; mouse; stereotactic; transcranial; NEURONAVIGATION; HISTOTRIPSY; ABLATION; BARRIER;

D O I：

10.1109/TUFFC.2020.3012303

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

An inexpensive, accurate focused ultrasound stereotactic targeting method guided by pretreatment magnetic resonanceimaging (MRI) images formurine brainmodels is presented. An uncertainty of each sub-component of the stereotactic system was analyzed. The entire system was calibrated using clot phantoms. The targeting accuracy of the system was demonstrated with an in vivo mouse glioblastoma ( GBM) model. The accuracy was quantified by the absolute distance difference between the prescribed and ablated points visible on the pre treatment and post-treatment MR images, respectively. A precalibration phantom study (N = 6) resulted in an error of 0.32 +/- 0.31, 0.72 +/- 0.16, and 1.06 +/- 0.38 mm in axial, lateral, and elevational axes, respectively. A postcalibration phantom study (N = 8) demonstrated a residual error of 0.09 +/- 0.01, 0.15 +/- 0.09, and 0.47 +/- 0.18 mm in axial, lateral, and elevational axes, respectively. The calibrated system showed significantly reduced (p < 0.05) error of 0.20 +/- 0.21, 0.34 +/- 0.24, and 0.28 +/- 0.21mmin axial, lateral, and elevationalaxes, respectively, in the in vivo GBM tumor-bearing mice (N = 10).

引用

页码：154 / 163

页数：10

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