Role of α-fetoprotein in hepatocellular carcinoma: prognostication, treatment monitoring or both?

被引：15
作者：
Chan, Stephen L. [2 ]
Chan, Anthony T. C. [2 ]
Yeo, Winnie [1 ]
机构：
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Shatin, Hong Kong, Peoples R China
来源：
FUTURE ONCOLOGY | 2009年 / 5卷 / 06期
关键词：
alpha-fetoprotein; hepatocellular carcinoma; monitoring treatment; prognostic factor; TRANSARTERIAL LIPIODOL CHEMOEMBOLIZATION; TRANSCATHETER ARTERIAL EMBOLIZATION; RANDOMIZED PHASE-III; MULTIVARIATE-ANALYSIS; STAGING SYSTEMS; COMBINATION CHEMOTHERAPY; RADIOFREQUENCY ABLATION; LIVER-TRANSPLANTATION; CIRRHOTIC-PATIENTS; NATURAL-HISTORY;
D O I：
10.2217/FON.09.64
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite recent breakthroughs in the treatment for both early and advanced hepatocellular carcinoma, the development of markers for prognostication and treatment monitoring remains to be explored. Serum alpha-fetoprotein has been frequently measured at diagnosis and serially during treatment by clinicians for decades, with an aim for prognostication of disease and monitoring of treatment response. In this review, the evidence regarding the prognostic value of serum alpha-fetoprotein and the value of serial alpha-fetoprotein In the monitoring of treatment efficacy will be discussed, with emphasis on recent data.
引用
收藏
页码：889 / 899
页数：11
相关论文
共 104 条
[51]   Sorafenib in advanced hepatocellular carcinoma [J].
Llovet, Josep M. ;
Ricci, Sergio ;
Mazzaferro, Vincenzo ;
Hilgard, Philip ;
Gane, Edward ;
Blanc, Jean-Frederic ;
Cosme de Oliveira, Andre ;
Santoro, Armando ;
Raoul, Jean-Luc ;
Forner, Alejandro ;
Schwartz, Myron ;
Porta, Camillo ;
Zeuzem, Stefan ;
Bolondi, Luigi ;
Greten, Tim F. ;
Galle, Peter R. ;
Seitz, Jean-Francois ;
Borbath, Ivan ;
Haussinger, Dieter ;
Giannaris, Tom ;
Shan, Minghua ;
Moscovici, Marius ;
Voliotis, Dimitris ;
Bruix, Jordi .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) :378-390
[52]   Novel advancements in the management of hepatocellular carcinoma in 2008 [J].
Llovet, Josep M. ;
Bruix, Jordi .
JOURNAL OF HEPATOLOGY, 2008, 48 :S20-S37
[53]   Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma [J].
Lo, CM ;
Ngan, H ;
Tso, WK ;
Liu, CL ;
Lam, CM ;
Poon, RTP ;
Fan, ST ;
Wong, J .
HEPATOLOGY, 2002, 35 (05) :1164-1171
[54]  
Lu JP, 2004, WORLD J GASTROENTERO, V10, P1730
[55]  
Manghisi G, 1998, HEPATOLOGY, V28, P751
[56]  
MATSUMOTO Y, 1982, CANCER-AM CANCER SOC, V49, P354, DOI 10.1002/1097-0142(19820115)49:2<354::AID-CNCR2820490224>3.0.CO
[57]  
2-J
[58]  
MCINTIRE KR, 1972, CANCER RES, V32, P1941
[59]  
MCINTIRE KR, 1975, CANCER RES, V35, P991
[60]  
MCINTIRE KR, 1976, CANCER-AM CANCER SOC, V37, P677, DOI 10.1002/1097-0142(197602)37:2<677::AID-CNCR2820370211>3.0.CO
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