Epigenetic alterations underlying autoimmune diseases

被引：78

作者：

Aslani, Saeed ^{[1
]}

Mahmoudi, Mahdi ^{[2
]}

Karami, Jafar ^{[1
]}

Jamshidi, Ahmad Reza ^{[2
]}

Malekshahi, Zahra ^{[1
]}

Nicknam, Mohammad Hossein ^{[1
,3
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[2] Univ Tehran Med Sci, Rheumatol Res Ctr, Kargar Ave,POB 1411713137, Tehran, Iran

[3] Univ Tehran Med Sci, Mol Immunol Res Ctr, Tehran, Iran

来源：

AUTOIMMUNITY | 2016年 / 49卷 / 02期

基金：

美国国家科学基金会;

关键词：

histone acetylation; environment; Autoimmune disease; DNA methylation; epigenetics; CD4(+) T-CELLS; WIDE DNA METHYLATION; HISTONE MODIFICATION PATTERNS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PRIMARY BILIARY-CIRRHOSIS; NAIVE CD4+T CELLS; RHEUMATOID-ARTHRITIS; MESSENGER-RNA; ANKYLOSING-SPONDYLITIS; PROMOTER METHYLATION;

D O I：

10.3109/08916934.2015.1134511

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent breakthroughs in genetic explorations have extended our understanding through discovery of genetic patterns subjected to autoimmune diseases (AID). Genetics, on the contrary, has not answered all the conundrums to describe a comprehensive explanation of causal mechanisms of disease etiopathology with regard to the function of environment, sex, or aging. The other side of the coin, epigenetics which is defined by gene manifestation modification without DNA sequence alteration, reportedly has come in to provide new insights towards disease apprehension through bridging the genetics and environmental factors. New investigations in genetic and environmental contributing factors for autoimmunity provide new explanation whereby the interactions between genetic elements and epigenetic modifications signed by environmental agents may be responsible for autoimmune disease initiation and perpetuation. It is aimed through this article to review recent progress attempting to reveal how epigenetics associates with the pathogenesis of autoimmune diseases.

引用

页码：69 / 83

页数：15

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