Glycemic index, glycemic load and renal cell carcinoma risk

被引：15

作者：

Galeone, C. ^{[1
,2
]}

Pelucchi, C. ^{[1
]}

Dal Maso, L. ^{[3
]}

Negri, E. ^{[1
]}

Talamini, R. ^{[3
]}

Montella, M. ^{[4
]}

Ramazzotti, V. ^{[5
]}

Bellocco, R. ^{[6
,7
]}

Franceschi, S. ^{[8
]}

La Vecchia, C. ^{[1
,2
]}

机构：

[1] Ist Ric Farmacol Mario Negri, Dipartimento Epidemiol, I-20156 Milan, Italy

[2] Univ Milan, Inst Med Stat & Biometry GA Maccacaro, Milan, Italy

[3] Natl Canc Inst, Unit Epidemiol & Biostat, Aviano, Italy

[4] Natl Canc Inst, Fdn G Pascale, Dept Epidemiol, Naples, Italy

[5] Natl Canc Inst Regina Elena, Dept Epidemiol, Rome, Italy

[6] Univ Milano Bicocca, Dept Stat, Milan, Italy

[7] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[8] Int Agcy Res Canc, F-69372 Lyon, France

来源：

ANNALS OF ONCOLOGY | 2009年 / 20卷 / 11期

关键词：

cancer risk; case-control studies; diet; glycemic index; glycemic load; renal cell carcinoma; DIABETES-MELLITUS; CANCER-RISK; ALCOHOL-CONSUMPTION; CHRONIC DISEASE; ADULTS; METAANALYSIS; INSULIN;

D O I：

10.1093/annonc/mdp197

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Materials and methods: Cases were 767 patients with histologically confirmed, incident RCC. Controls were 1534 subjects admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic conditions, unrelated to known risk factors for RCC. Information on dietary habits was derived through a food-frequency questionnaire. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for GI and GL intake were adjusted for major relevant covariates. Results: Compared with the lowest quintile, the ORs for the highest quintile were 1.43 (95% CI 1.05-1.95) for GI and 2.56 (95% CI 1.78-3.70) for GL, with significant trends in risk. Compared with the lowest quintile, the risk of RCC for all subsequent levels of GL was higher in never drinkers than in ever drinkers. Conclusions: We found direct relations between dietary levels of GI and GL and RCC risk. This can be related to mechanisms linked to insulin resistance and sensitivity.

引用

页码：1881 / 1885

页数：5

共 30 条

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