Magnetic-NIR Persistent Luminescent Dual-Modal ZGOCS@MSNs@Gd2O3 Core-Shell Nanoprobes For In Vivo Imaging

Recently, Gd3+-based NIR persistent luminescence nanoparticles have been proposed as highly promising multimodal nanoprobes for full-scale visualization medical techniques in early diagnosis of cancer. However, they still face with some problems, such as hampering further functionalization for the loss of available surface, shortening plasma half-life of the probe caused by inevitable size increase, and reducing SNR because of significant persistent intensity loss. In this study, a novel core shell structure Gd3+-based NIR persistent luminescence multimodal probe ZGOCS@MSNs@Gd2O3 for Trweighted MR imaging and NIR persistent luminescence imaging was successfully synthesized using MSNs as the reaction vessels for ZGOCS nanoparticles and the core for Gd2O3 shell. Compared with previously reported Gd3+-based NIR persistent luminescence-based multimodal nanoprobes, the as-prepared nanoparticles enable surface available, no persistent intensity loss and only a slight size increase. Moreover, this multifunctional nanoprobe not only retains excellent NIR persistent luminescence properties with rechargeable ability, but also possesses high longitudinal relaxivity via the Gd2O3 shell, positioning ZGOCS@MSNs@Gd2O3 as highly promising nanoprobe for future multimodal bioimaging.