Traditional Chinese Medicine and regulatory roles on epithelial-mesenchymal transitions

被引：16

作者：

Bai, Jing ^{[1
]}

Kwok, Wee Chiew ^{[2
]}

Thiery, Jean-Paul ^{[3
]}

机构：

[1] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore

[3] Guangdong Lab, Guangzhou Regenerat Med & Hlth, Guangzhou, Guangdong, Peoples R China

来源：

CHINESE MEDICINE | 2019年 / 14卷 / 01期

关键词：

Epithelial-mesenchymal transition; Traditional Chinese Medicine; Fibrosis; Wound-repair; Cancer invasion and metastasis; Stromal cells; GROWTH-FACTOR-BETA; RENAL INTERSTITIAL FIBROSIS; HUMAN COLORECTAL-CANCER; E-CADHERIN REPRESSION; NF-KAPPA-B; TGF-BETA; LUNG-CANCER; IN-VITRO; SIGNALING PATHWAY; MIR-200; FAMILY;

D O I：

10.1186/s13020-019-0257-6

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Epithelial-mesenchymal transition (EMT) is a critical biological process allowing epithelial cells to de-differentiate into mesenchymal cells. Orchestrated signaling pathways cooperatively induce EMT and effect physiological, sometimes pathological outcomes. Traditional Chinese Medicine (TCM) has been clinically prescribed for thousands of years and recent studies have found that TCM therapies can participate in EMT regulation. In this review, the historical discovery of EMT will be introduced, followed by a brief overview of its major roles in development and diseases. The second section will focus on EMT in organ fibrosis and tissue regeneration. The third section discusses EMT-induced cancer metastasis, and details how EMT contribute to distant dissemination. Finally, new EMT players are described, namely microRNA, epigenetic modifications, and alternative splicing. TCM drugs that affect EMT proven through an evidence-based research approach will be presented in each section.

引用

页数：13

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