Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

被引：72

作者：

Jiang, Ao ^{[1
]}

Chen, Guang ^{[1
]}

Xu, Jie ^{[1
]}

Liu, Yuxia ^{[1
]}

Zhao, Guanghui ^{[1
]}

Liu, Zhenjun ^{[1
]}

Chen, Tao ^{[1
,2
,3
]}

Li, Yulin ^{[1
,2
,3
]}

James, Tony D. ^{[1
,4
]}

机构：

[1] Qufu Normal Univ, Key Lab Life Organ Anal, Key Lab Pharmaceut Intermediates & Anal Nat Med, Coll Chem & Chem Engn, Qufu 273165, Peoples R China

[2] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China

[3] Chinese Acad Sci, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Northwest Inst Plateau Biol, Xining 810001, Qinghai, Peoples R China

[4] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 76期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

LIVING CELLS; PH;

D O I：

10.1039/c9cc05759e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.

引用

收藏

页码：11358 / 11361

页数：4

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