Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network

被引：171
|
作者：
Linghu, Bolan [1 ]
Snitkin, Evan S. [1 ]
Hu, Zhenjun [1 ]
Xia, Yu [1 ,2 ]
DeLisi, Charles [1 ]
机构：
[1] Boston Univ, Bioinformat Program, Boston, MA 02215 USA
[2] Boston Univ, Dept Chem, Boston, MA 02215 USA
来源：
GENOME BIOLOGY | 2009年 / 10卷 / 09期
关键词：
PROTEIN-INTERACTION NETWORK; CANDIDATE GENES; LIPID-METABOLISM; PREDICTION; DATABASE; ANNOTATION; EXPRESSION; RESOURCE; VISANT; VISUALIZATION;
D O I：
10.1186/gb-2009-10-9-r91
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phenotypes, such as hypercholesterolemia and Alzheimer's disease. Many of these disease-disease associations are supported by epidemiology, but with no previous genetic basis. Such associations can drive novel hypotheses on molecular mechanisms of diseases and therapies.
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页数：17
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