Genetic predisposition and children infectious disease

被引：4

作者：

Picard, C.

Filipe-Santos, O.

Chapgier, A.

von Bernuth, H.

Vogt, G.

Casanova, J. -L.

机构：

[1] Hop Necker Enfants Malad, Assistance Publ Hop Paris, Ctr Etud Deficits Immunitaires, F-75015 Paris, France

[2] Univ Paris 05, INSERM, U 550, Fac Med Necker,Lab Genet Humaine Malad Infect, F-75015 Paris, France

[3] Hop Necker Enfants Malad, Assistance Publ Hop Paris, Unite Immunol Hematol Pediat, F-75015 Paris, France

来源：

ARCHIVES DE PEDIATRIE | 2006年 / 13卷 / 10期

关键词：

immunodeficiency; genetic predisposition; mycobacterial infections; pneumococcal infections; viral infections; child;

D O I：

10.1016/j.arcped.2006.07.009

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The classic primary immunodeficiencies confer predisposition to multiple infectious diseases. However since ten years severe pediatric infections which were idiopathic have now molecular explanation. Indeed, defects in several genes confer a predisposition to infection with specific pathogenes in otherwise healthy individuals. These children present a new kind of hereditary immunodeficiency with severe and/or recurrent infections caused by only one microorganisms family, in opposition of others patients with "classic" primary immunodeficiency. (c) 2006 Elsevier SAS. Tous droits reserves.

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收藏

页码：1342 / 1346

页数：5

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