Membrane Oxidation in Cell Delivery and Cell Killing Applications

被引：114

作者：

Wang, Ting-Yi ^{[1
]}

Libardo, M. Daben J. ^{[2
]}

Angeles-Boza, Alfredo M. ^{[2
]}

Pellois, Jean-Philippe ^{[1
,3
]}

机构：

[1] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

[2] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

[3] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

来源：

ACS CHEMICAL BIOLOGY | 2017年 / 12卷 / 05期

关键词：

GRAM-NEGATIVE BACTERIA; ARGININE-RICH PEPTIDES; PLASMID DNA DELIVERY; PENETRATING PEPTIDES; LIPID-PEROXIDATION; REACTIVE-OXYGEN; OXIDIZED PHOSPHOLIPIDS; ANTIMICROBIAL PEPTIDE; ESCHERICHIA-COLI; PHOTOCHEMICAL INTERNALIZATION;

D O I：

10.1021/acschembio.7b00237

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell delivery or cell killing processes often involve the crossing or disruption of cellular membranes. We review how, by modifying the composition and properties of membranes, membrane oxidation can be exploited to enhance the delivery of macromolecular cargoes into live human cells. We also describe how membrane oxidation can be utilized to achieve efficient killing of bacteria by antimicrobial peptides. Finally, we present recent evidence highlighting how membrane oxidation is intimately engaged in natural biological processes such as antigen delivery in dendritic cells and in the killing of bacteria by antimicrobial peptides. Overall, the insights that have been recently gained in this area should facilitate the development of more effective delivery technologies and antimicrobial therapeutic approaches.

引用

页码：1170 / 1182

页数：13

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