Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells

被引：57

作者：

Armstrong, Christine A. ^{[1
,2
]}

Tomita, Kazunori ^{[1
]}

机构：

[1] UCL, UCL Canc Inst, Chromosome Maintenance Grp, 72 Huntley St, London WC1E 6DD, England

[2] Aberdeen Royal Infirm, Med Microbiol, Link Bldg,Foresterhill, Aberdeen AB25 2ZN, Scotland

来源：

OPEN BIOLOGY | 2017年 / 7卷 / 03期

基金：

欧洲研究理事会;

关键词：

shelterin; telomere length homeostasis; replicative senescence; Hayflick limit; t-stumps; S; pombe; REVERSE-TRANSCRIPTASE HTERT; TO-END FUSIONS; OB-FOLD DOMAIN; FISSION YEAST; CHROMOSOME ENDS; IN-VITRO; SCHIZOSACCHAROMYCES-POMBE; BINDING-PROTEIN; SACCHAROMYCES-CEREVISIAE; LENGTH HOMEOSTASIS;

D O I：

10.1098/rsob.160338

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cancer cells to bypass their proliferative limit, rendering them immortal. The activity of telomerase is tightly controlled at multiple levels, from transcriptional regulation of the telomerase components to holoenzyme biogenesis and recruitment to the telomere, and finally activation and processivity. However, studies using cancer cell lines and other model systems have begun to reveal features of telomeres and telomerase that are unique to cancer. This review summarizes our current knowledge on the mechanisms of telomerase recruitment and activation using insights from studies in mammals and budding and fission yeasts. Finally, we discuss the differences in telomere homeostasis between normal cells and cancer cells, which may provide a foundation for telomere/telomerase targeted cancer treatments.

引用

页数：13

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