Effect of nitrofurans and NO generators on biofilm formation by Pseudomonas aeruginosa PAO1 and Burkholderia cenocepacia 370

被引：29

作者：

Zaitseva, Julia ^{[1
]}

Granik, Vladimir ^{[2
]}

Belik, Alexandr ^{[1
]}

Koksharova, Olga ^{[3
]}

Khmel, Inessa ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Mol Genet, Lab Regulat Express Microorganisms Genes, Moscow 123182, Russia

[2] State Res Ctr Antibiot, Dept Med Chem, Moscow 117105, Russia

[3] Moscow MV Lomonosov State Univ, Dept Bioengn, AN Belozersky Inst Phys Chem Biol, Moscow 119992, Russia

来源：

RESEARCH IN MICROBIOLOGY | 2009年 / 160卷 / 05期

关键词：

Biofilms; Nitrofurans; NO; NO donors; Pseudomonas aeruginosa; Burkholderia cenocepacia; NITRIC-OXIDE; ESCHERICHIA-COLI; BACTERIAL BIOFILM; INFECTIONS; ANTIBIOTICS; INVOLVEMENT; DISPERSAL;

D O I：

10.1016/j.resmic.2009.04.007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibacterial drugs in the nitrofuran series, such as nitrofurazone, furazidin, nitrofurantoin and nifuroxazide, as well as the nitric oxide generators sodium nitroprusside and isosorbide mononitrate in concentrations that do not suppress bacterial growth, were shown to increase the capacity of pathogenic bacteria Pseudomonas aeruginosa PAO1 and Burkholderia cenocepacia 370 to form biofilms. At 25-100 mu g/ml, nitrofurans 2-2.5-fold enhanced biofilm formation of P. aeruginosa PAO1, and NO donors 3-6-fold. For B. cenocepacia 370, the enhancement was 2-5-fold (nitrofurans) and 4.5-fold (sodium nitroprusside), respectively. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：353 / 357

页数：5

共 18 条

[1]

[Anonymous], HYDROLYSIS DRUG PROD

[2] Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa [J].

Barraud, Nicolas ;

Hassett, Daniel J. ;

Hwang, Sung-Hei ;

Rice, Scott A. ;

Kjelleberg, Staffan ;

Webb, Jeremy S. .

JOURNAL OF BACTERIOLOGY, 2006, 188 (21) :7344-7353

[3] Inducible nitric oxide synthase and control of intracellular bacterial pathogens [J].

Chakravortty, D ;

Hensel, M .

MICROBES AND INFECTION, 2003, 5 (07) :621-627

[4] Bacterial biofilms: A common cause of persistent infections [J].

Costerton, JW ;

Stewart, PS ;

Greenberg, EP .

SCIENCE, 1999, 284 (5418) :1318-1322

[5] The involvement of cell-to-cell signals in the development of a bacterial biofilm [J].

Davies, DG ;

Parsek, MR ;

Pearson, JP ;

Iglewski, BH ;

Costerton, JW ;

Greenberg, EP .

SCIENCE, 1998, 280 (5361) :295-298

[6] NO INHIBITIONS - ANTIMICROBIAL PROPERTIES OF NITRIC-OXIDE [J].

DEGROOTE, MA ;

FANG, FC .

CLINICAL INFECTIOUS DISEASES, 1995, 21 :S162-S165

[7]

GRANIK VG, 2004, NITRIC OXIDE NO NEW, P196

[8] An update on the role of nitrofurans in the management of urinary tract infections [J].

Guay, DR .

DRUGS, 2001, 61 (03) :353-364

[9]

Hentzer M, 2003, J CLIN INVEST, V112, P1300, DOI 10.1172/JCI20074

[10] EFFECT OF DIFFERENT NITROHETEROCYCLIC COMPOUNDS ON AEROBIC, MICROAEROPHILIC, AND ANAEROBIC-BACTERIA [J].

HOF, H ;

STRODER, J ;

BUISSON, JP ;

ROYER, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (05) :679-683

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