Cloning, chromosomal localization and expression patterns of porcine Kruppel-like factors 4, -5, -7 and the early growth response factor 2

被引：11

作者：

Yang, H. W. ^{[1
]}

Xia, T. ^{[1
]}

Chen, Z. L. ^{[1
]}

Feng, S. Q. ^{[1
]}

Peng, Y. ^{[1
]}

Zhou, L. ^{[1
]}

Gan, L. ^{[1
]}

Yang, Z. Q. ^{[1
]}

机构：

[1] Huazhong Agr Univ, Biochem Lab, Coll Life Sci & Technol, Wuhan 430070, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2007年 / 29卷 / 01期

关键词：

chromosomal mapping; cloning; Kruppel-like factors; pigs; the early growth response factor 2; tissue expression patterns;

D O I：

10.1007/s10529-006-9212-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Kruppel-like factors (KLF) and the early growth response factor 2 (EGR2) are important zinc finger transcription factors in vertebrates. We have cloned the full length coding sequence (CDS) of porcine KLF5, KLF7 and EGR2, which are 1374, 909 and 1416 bp, respectively. KLF4, KLF5 and EGR2 were then chromosomally mapped to porcine 1q28-29, 11q13-14 and 14q23-25, respectively. Moreover, the tissue expression patterns of KLF4, KLF5, KLF7 and EGR2 imply their probable roles in specific tissues. This is the first report of the basic study of these zinc finger transcription factors in pigs; this information will be helpful for future functional studies.

引用

页码：157 / 163

页数：7

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