Rational Design of Amyloid Binding Agents Based on the Molecular Rotor Motif

被引：64

作者：

Sutharsan, Jeyanthy ^{[1
]}

Dakanali, Marianna ^{[1
]}

Capule, Christina C. ^{[1
]}

Haidekker, Mark A. ^{[2
]}

Yang, Jerry ^{[1
]}

Theodorakis, Emmanuel A. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Georgia, Fac Engn, Athens, GA 30602 USA

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 01期

关键词：

amyloid peptides; fluorescent probes; imaging agents; molecular rotors; ALZHEIMERS-DISEASE; FLUORESCENT-PROBES; THIOFLAVIN-T; IMAGING AGENTS; VISCOSITY; AGGREGATION; DERIVATIVES; SURFACE; BRAIN;

D O I：

10.1002/cmdc.200900440

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New fluorescent probes, designed based on the molecular rotor motif, displayed good affinity for aggregated b-amyloid peptides. The physical and fluorescence properties of these probes can be fine tuned by modifying their chemical structures. These findings suggest that the general motif of molecular rotors can lead to the design of new diagnostic tools for amyloid imaging in Alzheimer's disease and related neurodegenerative conditions. (Chemical Equation Presented). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：56 / 60

页数：5

共 57 条

[1] Diastereodifferentiation of novel naphthalene dyads by fluorescence quenching and excimer formation [J].

Abad, Sergio ;

Vaya, Ignacio ;

Jimenez, M. Consuelo ;

Pischel, Uwe ;

Miranda, Miguel A. .

CHEMPHYSCHEM, 2006, 7 (10) :2175-2183

[2] Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for β-amyloid plaques in Alzheimer's disease [J].

Agdeppa, ED ;

Kepe, V ;

Liu, J ;

Flores-Torres, S ;

Satyamurthy, N ;

Petric, A ;

Cole, GM ;

Small, GW ;

Huang, SC ;

Barrio, JR .

JOURNAL OF NEUROSCIENCE, 2001, 21 (24) :art. no.-RC189

[3] Imaging amyloid-β deposits in vivo [J].

Bacskai, BJ ;

Klunk, WE ;

Mathis, CA ;

Hyman, BT .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2002, 22 (09) :1035-1041

[4] Aromatic Cross-Strand Ladders Control the Structure and Stability of β-Rich Peptide Self-Assembly Mimics [J].

Biancalana, Matthew ;

Makabe, Koki ;

Koide, Akiko ;

Koide, Shohel .

JOURNAL OF MOLECULAR BIOLOGY, 2008, 383 (01) :205-213

[5] Molecular Mechanism of Thioflavin-T Binding to the Surface of β-Rich Peptide Self-Assemblies [J].

Biancalana, Matthew ;

Makabe, Koki ;

Koide, Akiko ;

Koide, Shohei .

JOURNAL OF MOLECULAR BIOLOGY, 2009, 385 (04) :1052-1063

[6] Use of functional imaging in parkinsonism and dementia [J].

Burn, DJ ;

O'Brien, JT .

MOVEMENT DISORDERS, 2003, 18 :S88-S95

[7] Synthesis and properties of 1-(4-aminophenyl)-2,4-dicyano-3-diethylamino-9,9-diethylfluorenes: Potential fluorescent material [J].

Chen, Xiao-Hang ;

Zhao, Zujin ;

Liu, Yang ;

Lu, Ping ;

Wang, Yan-Guang .

CHEMISTRY LETTERS, 2008, 37 (06) :570-571

[8] Fluorescent probes for detection of amphiphilic polymer hydrophobic microdomains: A comparative study between pyrene and molecular rotors [J].

Damas, C ;

Adibnejad, M ;

Benjelloun, A ;

Brembilla, A ;

Carre, MC ;

Viriot, ML ;

Lochon, P .

COLLOID AND POLYMER SCIENCE, 1997, 275 (04) :364-371

[9] STUDIES IN NEWTONIAN FLOW .3. THE DEPENDENCE OF THE VISCOSITY OF LIQUIDS ON MOLECULAR WEIGHT AND FREE SPACE (IN HOMOLOGOUS SERIES) [J].

DOOLITTLE, AK .

JOURNAL OF APPLIED PHYSICS, 1952, 23 (02) :236-239

[10] Fluorescence as a characterization tool to study amphiphilic polymer aggregation in aqueous media [J].

Frochot, C ;

Muller, C ;

Brembilla, A ;

Carré, MC ;

Lochon, P ;

Viriot, ML .

INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION, 2000, 6 (1-2) :109-122

← 1 2 3 4 5 6 →