Factors associated with stillbirth in women with diabetes

被引:63
作者
Mackin, Sharon T. [1 ]
Nelson, Scott M. [2 ]
Wild, Sarah H. [3 ]
Colhoun, Helen M. [4 ]
Wood, Rachael [5 ]
Lindsay, Robert S. [1 ]
Gribble, S.
Abubaker, A.
Barnett, A.
Fischbacher, C.
Pearson, E.
Leese, G.
Chalmers, J.
Mcknight, J.
Petrie, J.
Sattar, N.
Wu, O.
McCrimmon, R.
Philip, S.
Cunningham, S.
机构
[1] Univ Glasgow, British Heart Fdn Glasgow Cardiovasc Res Ctr, Inst Cardiovasc & Med Sci, 126 Univ Pl, Glasgow G12 8TA, Lanark, Scotland
[2] Univ Glasgow, Sch Med, Glasgow, Lanark, Scotland
[3] Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland
[4] Univ Edinburgh, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland
[5] ISD Scotland, Edinburgh, Midlothian, Scotland
关键词
Birthweight; Epidemiology; Neonatal; Pregnancy; Stillbirth; Type; 1; diabetes; 2; PREGNANCY OUTCOMES; INFANT-DEATH; WEIGHT-GAIN; TYPE-1; RISK; FETAL; MORTALITY; MELLITUS;
D O I
10.1007/s00125-019-4943-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims/hypothesis Stillbirth risk is increased in pregnancy complicated by diabetes. Fear of stillbirth has major influence on obstetric management, particularly timing of delivery. We analysed population-level data from Scotland to describe timing of stillbirths in women with diabetes and associated risk factors. Methods A retrospective cohort of singleton deliveries to mothers with type 1 (n = 3778) and type 2 diabetes (n = 1614) from 1 April 1998 to 30 June 2016 was analysed using linked routine care datasets. Maternal and fetal characteristics, HbA(1c) data and delivery timing were compared between stillborn and liveborn groups. Results Stillbirth rates were 16.1 (95% CI 12.4, 20.8) and 22.9 (95% CI 16.4, 31.8) per 1000 births in women with type 1 (n = 61) and type 2 diabetes (n = 37), respectively. In women with type 1 diabetes, higher HbA(1c) before pregnancy (OR 1.03 [95% CI 1.01, 1.04]; p = 0.0003) and in later pregnancy (OR 1.06 [95% CI 1.04, 1.08]; p < 0.0001) were associated with stillbirth, while in women with type 2 diabetes, higher maternal BMI (OR 1.07 [95% CI 1.01, 1.14]; p = 0.02) and pre-pregnancy HbA(1c) (OR 1.02 [95% CI 1.00, 1.04]; p = 0.016) were associated with stillbirth. Risk was highest in infants with birthweights <10th centile (sixfold higher born to women with type 1 diabetes [n = 5 stillbirths, 67 livebirths]; threefold higher for women with type 2 diabetes [n = 4 stillbirths, 78 livebirths]) compared with those in the 10th-90th centile (n = 20 stillbirths, 1685 livebirths). Risk was twofold higher in infants with birthweights >95th centile born to women with type 2 diabetes (n = 15 stillbirths, 402 livebirths). A high proportion of stillborn infants were male among mothers with type 2 diabetes (81.1% vs 50.5% livebirths, p = 0.0002). A third of stillbirths occurred at term, with highest rates in the 38th week (7.0 [95% CI 3.7, 12.9] per 1000 ongoing pregnancies) among mothers with type 1 diabetes and in the 39th week (9.3 [95% CI 2.4, 29.2]) for type 2 diabetes. Conclusions/interpretation Maternal blood glucose levels and BMI are important modifiable risk factors for stillbirth in diabetes. Babies at extremes of weight centiles are at most risk. Many stillbirths occur at term and could potentially be prevented by change in routine care and delivery policies.
引用
收藏
页码:1938 / 1947
页数:10
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