Structural Biology of the Zika Virus

被引：107

作者：

Shi, Yi ^{[1
,2
,3
,4
]}

Gao, George F. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[2] Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen, Peoples R China

[3] Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing, Peoples R China

[4] Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China

[5] Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2017年 / 42卷 / 06期

基金：

中国国家自然科学基金;

关键词：

WEST-NILE-VIRUS; CROSS-REACTIVE ANTIBODIES; DEPENDENT RNA-POLYMERASE; FC-GAMMA-RECEPTOR; DENGUE VIRUS; CRYSTAL-STRUCTURE; PROTEIN NS1; NS2B-NS3; PROTEASE; MEMBRANE ASSOCIATION; ENVELOPE PROTEIN;

D O I：

10.1016/j.tibs.2017.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zika virus (ZIKV), a Flaviviridae family member transmitted to humans by mosquitoes, has emerged as a major health concern. ZIKV infections can cause serious neurological complications in adults, and infection in pregnant women can cause congenital malformations, including fetal and newborn microcephaly. In response to this emerging concern, the structural virology field was quick to explore the features of ZIKV. These efforts have provided significant insights into ZIKV pathogenesis, and have identified targets for drug design. Here, we review the remarkable progress in structure-based ZIKV research and discuss the current challenges and future opportunities.

引用

页码：443 / 456

页数：14

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