Nutritional Support with Endoluminal Stenting During Neoadjuvant Therapy for Esophageal Malignancy

被引:53
作者
Bower, Matthew [1 ]
Jones, Whitney [2 ]
Vessels, Ben [1 ]
Scoggins, Charles [1 ]
Martin, Robert [1 ]
机构
[1] Univ Louisville, James Graham Brown Canc Ctr, Div Surg Oncol, Dept Surg,Sch Med, Louisville, KY 40292 USA
[2] Midwest Gastroenterol Associates, Louisville, KY USA
关键词
PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; GASTROINTESTINAL CANCER; MULTIMODALITY THERAPY; ENTERAL NUTRITION; RANDOMIZED-TRIAL; PLASTIC STENTS; COMPLICATIONS; CHEMORADIATION; CHEMORADIOTHERAPY; METAANALYSIS;
D O I
10.1245/s10434-009-0630-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Perioperative nutrition remains a significant problem in patients undergoing neoadjuvant treatment for esophageal cancer. The aim of this study was to evaluate the effectiveness of esophageal stenting, feeding tube placement, or observation among esophageal cancer patients receiving neoadjuvant therapy. A review of our prospectively maintained database of esophageal cancer patients identified 58 patients who underwent neoadjuvant chemoradiotherapy. Operative complications, tolerance of neoadjuvant therapy, and nutritional outcomes were evaluated according to the type of nutritional adjunct used. A total of 25 patients received esophageal stenting with self-expanding silicone stents. Of these, 19 patients had feeding tubes placed (without stenting), and 14 nonstented patients were maintained on oral diets alone. Stent patients showed a lower rate of interruption of chemoradiotherapy (8% vs. 29% vs. 47%, P = .011). The stent group also demonstrated greater mean improvement in albumin levels (0.14 g/dL vs. -0.39 g/dL vs. -0.45 g/dL, P < .001) and less percentage body weight loss (1.5% vs. 4.2% vs. 5.5%, P < .001). Nasogastric tubes were used for additional nutritional supplementation during the last week of therapy for two stent patients. The rate of stent migration was 24%. Overall, 31% of patients did not go on to resection because of progression to metastatic disease. The rate of major operative complication was 20% vs. 47% vs. 43% among stent, feeding tube, and oral nutrition patients respectively (P = .130). Esophageal stenting in the neoadjuvant setting offers improved results compared with feeding tubes both in maintaining preoperative nutrition and in tolerance of neoadjuvant chemoradiotherapy. Future protocols of patients treated with multimodal therapy for cancer of the esophagus should investigate the potential therapeutic benefit of using removable silicone esophageal stents as an alternative to feeding tubes.
引用
收藏
页码:3161 / 3168
页数:8
相关论文
共 37 条
[1]  
[Anonymous], SEER Cancer Statistics Review, 1975-2001
[2]   Nutritional support in patients with cancer of the esophagus: Impact on nutritional status, patient compliance to therapy, and survival [J].
Bozzetti, F ;
Cozzaglio, L ;
Gavazzi, C ;
Bidoli, P ;
Bonfanti, G ;
Montalto, F ;
Parra, HS ;
Valente, M ;
Zucali, R .
TUMORI, 1998, 84 (06) :681-686
[3]   Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer: a randomised multicentre trial [J].
Bozzetti, F ;
Braga, M ;
Gianotti, L ;
Gavazzi, C ;
Mariani, L .
LANCET, 2001, 358 (9292) :1487-1492
[4]   Early postoperative enteral nutrition improves gut oxygenation and reduces costs compared with total parenteral nutrition [J].
Braga, M ;
Gianotti, L ;
Gentilini, O ;
Parisi, V ;
Salis, C ;
Di Carlo, V .
CRITICAL CARE MEDICINE, 2001, 29 (02) :242-248
[5]   Polyflex stents for malignant oesophageal and oesophagogastric stricture: a prospective, multicentric study [J].
Conigliaro, Rita ;
Battaglia, Giorgio ;
Repici, Alessandro ;
De Pretis, Giovanni ;
Ghezzo, Luigi ;
Bittinger, Max ;
Messmann, Helmut ;
Demarquay, Jean-Francois ;
Togni, Michele ;
Blanchi, Sabrina ;
Filiberti, Rosangela ;
Conio, Massimo .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2007, 19 (03) :195-203
[6]   Chemoradiotherapy of locally advanced esophageal cancer - Long-term follow-up of a prospective randomized trial (RTOG 85-01) [J].
Cooper, JS ;
Guo, MD ;
Herskovic, A ;
Macdonald, JS ;
Martenson, JA ;
Al-Sarraf, M ;
Byhardt, R ;
Russell, AH ;
Beitler, JJ ;
Spencer, S ;
Asbell, SO ;
Graham, MV ;
Leichman, LL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (17) :1623-1627
[7]   Prospective evaluation of a new self-expanding plastic stent for inoperable esophageal strictures [J].
Costamagna, G ;
Shah, SK ;
Tringali, A ;
Mutignani, M ;
Perri, V ;
Riccioni, ME .
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2003, 17 (06) :891-895
[8]   ENTERAL NUTRITION DURING MULTIMODALITY THERAPY IN UPPER GASTROINTESTINAL CANCER-PATIENTS [J].
DALY, JM ;
WEINTRAUB, FN ;
SHOU, J ;
ROSATO, EF ;
LUCIA, M .
ANNALS OF SURGERY, 1995, 221 (04) :327-338
[9]   PREOPERATIVE CHEMORADIATION FOLLOWED BY TRANSHIATAL ESOPHAGECTOMY FOR CARCINOMA OF THE ESOPHAGUS - FINAL REPORT [J].
FORASTIERE, AA ;
ORRINGER, MB ;
PEREZTAMAYO, C ;
URBA, SG ;
ZAHURAK, M .
JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (06) :1118-1123
[10]   Preoperative serum albumin level as a predictor of operative mortality and morbidity - Results from the national VA surgical risk study [J].
Gibbs, J ;
Cull, W ;
Henderson, W ;
Daley, J ;
Hur, K ;
Khuri, SF .
ARCHIVES OF SURGERY, 1999, 134 (01) :36-42