This work aims estimating seismic losses in residential-reinforced concrete buildings, highlighting the influence of infills and services. First, the mechanical-based "POST"-method is used to perform simplified (nonlinear static) structural analyses, in the "shear-type" building hypothesis. Then, drift-based fragility curves and repair cost analysis, specific for infills and services, are used to obtain expected damage and losses. Lastly, the whole proposed loss assessment methodology is applied to a wide building stock struck by L'Aquila (Italy) 2009-earthquake and damaged to infills. The numerical-versus-observed comparison of damage scenario and seismic losses allows a promising validation of the procedure.