Patient Perspectives on DMARD Safety Concerns in Rheumatology Trials: Results from Inflammatory Arthritis Patient Focus Groups and OMERACT Attendees Discussion

被引：10

作者：

Andersen, Kathleen M. ^{[1
,7
]}

Kelly, Ayano ^{[9
,10
,11
]}

Lyddiatt, Anne ^{[17
]}

Bingham, Clifton O., III ^{[17
]}

Bykerk, Vivian P. ^{[18
]}

Batterman, Adena ^{[19
]}

Westreich, Joan ^{[19
]}

Jones, Michelle K. ^{[18
]}

Cross, Marita ^{[13
,14
]}

Brooks, Peter M. ^{[15
,16
]}

March, Lyn ^{[12
,13
,14
]}

Shea, Beverley ^{[3
,5
]}

Tugwell, Peter ^{[4
,5
,6
]}

Simon, Lee S. ^{[20
]}

Christensen, Robin ^{[8
,21
]}

Bartlett, Susan J. ^{[2
,17
]}

机构：

[1] McGill Univ, Dept Family Med, Montreal, PQ, Canada

[2] McGill Univ, Dept Med, Montreal, PQ, Canada

[3] Ottawa Hosp, Ottawa Hosp Res Inst, Ottawa, ON, Canada

[4] Univ Ottawa, Fac Med, Div Rheumatol, Dept Med, Ottawa, ON, Canada

[5] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[6] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada

[7] Bispebjerg & Frederiksberg Hosp, Parker Inst, Musculoskeletal Stat Unit, Copenhagen, Denmark

[8] Odense Univ Hosp, Dept Rheumatol, Odense, Denmark

[9] Canberra Rheumatol, Canberra, ACT, Australia

[10] Australian Natl Univ, Coll Hlth & Med, Canberra, ACT, Australia

[11] Childrens Hosp Westmead, Ctr Kidney Res, Westmead, NSW, Australia

[12] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia

[13] Royal North Shore Hosp, Dept Rheumatol, St Leonards, NSW, Australia

[14] Northern Sydney Local Hlth Dist, Kolling Inst, Inst Bone & Joint Res, St Leonards, NSW, Australia

[15] Univ Melbourne, Ctr Hlth Policy, Sch Populat & Global Hlth, Melbourne, Vic, Australia

[16] Northern Hlth, Epping, NSW, Australia

[17] Johns Hopkins Univ, Dept Med, Div Rheumatol, Baltimore, MD USA

[18] Hosp Special Surg, Dept Med, Div Rheumatol, 535 E 70th St, New York, NY 10021 USA

[19] Hosp Special Surg, Dept Social Work Programs, 535 E 70th St, New York, NY 10021 USA

[20] SDG LLC, Cambridge, MA USA

[21] Bispebjerg & Frederiksberg Hosp, Parker Inst, Musculoskeletal Stat Unit, Biostat & Clin Epidemiol, Copenhagen, Denmark

来源：

JOURNAL OF RHEUMATOLOGY | 2019年 / 46卷 / 09期

基金：

美国国家卫生研究院;

关键词：

OMERACT; DRUG TOXICITY; RISK; PATIENT SATISFACTION; CLINICAL TRIALS; DISEASE-MODIFYING ANTIRHEUMATIC DRUGS; ADVERSE EVENTS; SETS;

D O I：

10.3899/jrheum.181185

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. The Outcome Measures in Rheumatology (OMERACT) Safety Working Group is identifying core safety domains that matter most to patients with rheumatic disease. Methods. International focus groups were held with 39 patients with inflammatory arthritis to identify disease-modifying antirheumatic drug (DMARD) experiences and concerns. Themes were identified by pragmatic thematic coding and discussed in small groups by meeting attendees. Results. Patients view DMARD side effects as a continuum and consider the cumulative effect on day-to-day function. Disease and drug experiences, personal factors, and life circumstances influence tolerance of side effects and treatment persistence. Conclusion. Patients weigh overall adverse effects and benefits over time in relation to experiences and life circumstances.

引用

页码：1168 / 1172

页数：5

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