The role of scaffold proteins in JNK signalling

被引：53

作者：

Engstrom, W. ^{[1
,2
]}

Ward, A. ^{[3
]}

Moorwood, K. ^{[3
]}

机构：

[1] Swedish Univ Agr Sci, Dept Biosci & Vet Publ Hlth, Div Pathol, S-75007 Uppsala, Sweden

[2] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

[3] Univ Bath, Ctr Regenerat Med, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

CELL PROLIFERATION | 2010年 / 43卷 / 01期

基金：

英国惠康基金;

关键词：

JUN NH2-TERMINAL KINASE; CYTOKINE-INDUCED APOPTOSIS; N-TERMINAL KINASE; GROWTH-FACTOR-II; FOCAL ADHESION KINASE; P38 MAP KINASE; C-JUN; INTERACTING PROTEIN; TRANSDUCTION PATHWAY; MOLECULAR SCAFFOLDS;

D O I：

10.1111/j.1365-2184.2009.00654.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This paper summarises how scaffold proteins affects and regulate the JNK signalling pathway. We believe that some of these scaffold proteins, by virtue of their anchoring and catalytic properties contribute to a high degree of specificity of intra cellular signalling pathways that regulate the progression through the cell cycle.

引用

页码：56 / 66

页数：11

共 92 条

[1] Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis [J].

Basu, A ;

Haldar, S .

FEBS LETTERS, 2003, 538 (1-3) :41-47

[2] Macrophage glucocorticoid receptors regulate toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase [J].

Bhattacharyya, Sandip ;

Brown, Diane E. ;

Brewer, Judson A. ;

Vogt, Sherri K. ;

Muglia, Louis J. .

BLOOD, 2007, 109 (10) :4313-4319

[3] Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein [J].

Blanco, Sandra ;

Sanz-Garcia, Marta ;

Santos, Claudio R. ;

Lazo, Pedro A. .

PLOS ONE, 2008, 3 (02)

[4] Counting on mitogen-activated protein kinases - ERKs 3, 4, 5, 6, 7 and 8 [J].

Bogoyevitch, MA ;

Court, NW .

CELLULAR SIGNALLING, 2004, 16 (12) :1345-1354

[5] The isoform-specific functions of the c-Jun N-terminal kinases (JNKs): differences revealed by gene targeting [J].

Bogoyevitch, Marie A. .

BIOESSAYS, 2006, 28 (09) :923-934

[6] The kinase domain of MEKK1 induces apoptosis by dysregulation of MAP kinase pathways [J].

Boldt, S ;

Weidle, UH ;

Kolch, W .

EXPERIMENTAL CELL RESEARCH, 2003, 283 (01) :80-90

[7] Targeting MAPK signalling: Prometheus' fire or pandora's box? [J].

Boldt, S ;

Kolch, W .

CURRENT PHARMACEUTICAL DESIGN, 2004, 10 (16) :1885-1905

[8] IB1 reduces cytokine-induced apoptosis of insulin-secreting cells [J].

Bonny, C ;

Oberson, A ;

Steinmann, M ;

Schorderet, DF ;

Nicod, P ;

Waeber, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (22) :16466-16472

[9] Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade [J].

Buchsbaum, RJ ;

Connolly, BA ;

Feig, LA .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (12) :4073-4085

[10] Signal transduction: hanging on a scaffold [J].

Burack, WR ;

Shaw, AS .

CURRENT OPINION IN CELL BIOLOGY, 2000, 12 (02) :211-216

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