Molecular epidemiology of vancomycin-resistant Enterococcus faecium in Argentina

被引：26

作者：

Corso, Alejandra C. ^{[1
]}

Gagetti, Paula S. ^{[1
]}

Rodriguez, Marisa M. ^{[1
]}

Melano, Roberto G. ^{[1
]}

Ceriana, Paola G. ^{[1
]}

Faccone, Diego F. ^{[1
]}

Galas, Marcelo F. ^{[1
]}

机构：

[1] Inst Nacl Enfermedades Infecciosas ANLIS Dr Carlo, Serv Antimicrobianos, RA-1281 Buenos Aires, DF, Argentina

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2007年 / 11卷 / 01期

关键词：

Argentina; clonal dissemination; Enterococcus faecium; glycopeptide resistance; typing; vancomycin-resistant enterococci;

D O I：

10.1016/j.ijid.2006.02.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective: To characterize the mechanism of glycopeptide resistance and to determine the genetic relatedness among strains by pulsed-field get electrophoresis (PFGE) in vancomycin-resistant Enterococcus faecium from Argentina. Materials and methods: A total of 189 vancomycin-resistant single-patient isolates of Enterococcus faecium recovered between January 1997 and December 2000 from 30 hospitals in Argentina were studied. Minimum inhibitory concentrations were determined by the agar dilution method and van genes were detected by PCR. PFGE was used for molecular typing. Results: All. isolates except three (vanB) were of genotype vanA. For 189 vancomycin-resistant Enterococcus faecium, Smal-PFGE indicated 35 clonal types. Most of the isolates (56%) belonged to the same clonal type 1, which was present in 19 hospitals and dominant in 17. Conclusions: The emergence of vancomycin- resistant Enterococcus faecium in Argentina seems to be related to the intra- and inter-hospital dissemination of an epidemic clone carrying the vanA element. (c) 2006 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：69 / 75

页数：7

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