OPINION Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery

被引：56

作者：

Barnes, Michael R. ^{[1
]}

Harland, Lee ^{[2
]}

Foord, Steven M. ^{[1
]}

Hall, Matthew D. ^{[1
]}

Dix, Ian ^{[3
]}

Thomas, Scott ^{[4
]}

Williams-Jones, Bryn I. ^{[5
,6
]}

Brouwer, Cory R. ^{[5
,6
]}

机构：

[1] GlaxoSmithKline, Dept Computat Biol, Harlow, Essex, England

[2] Pfizer Regenerat Med, Cambridge, England

[3] AstraZeneca, Discovery Informat, Macclesfield, Cheshire, England

[4] AstraZeneca, Discovery Informat, Waltham, MA USA

[5] Pfizer Ltd, eBiol Grp, Sandwich CT13 9NJ, Kent, England

[6] Pfizer Ltd, Computat Sci Ctr Excellence, Sandwich CT13 9NJ, Kent, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2009年 / 8卷 / 09期

关键词：

DATABASE; BIOLOGY; GENOME; IDENTIFICATION; RESOURCE; GENETICS;

D O I：

10.1038/nrd2944

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pharmaceutical research and development is facing substantial challenges that have prompted the industry to shift funding from early- to late-stage projects. Among the effects is a major change in the attitude of many companies to their internal bioinformatics resources: the focus has moved from the vigorous pursuit of intellectual property towards exploration of pre-competitive cross-industry collaborations and engagement with the public domain. High-quality, open and accessible data are the foundation of pre-competitive research, and strong public-private partnerships have considerable potential to enhance public data resources, which would benefit everyone engaged in drug discovery. In this article, we discuss the background to these changes and propose new areas of collaboration in computational biology and chemistry between the public domain and the pharmaceutical industry.

引用

页码：701 / 708

页数：8

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