Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

被引：2697

作者：

Doehner, Hartmut ^{[1
]}

Estey, Elihu H. ^{[2
]}

Amadori, Sergio ^{[3
]}

Appelbaum, Frederick R. ^{[4
]}

Buechner, Thomas ^{[5
]}

Burnett, Alan K. ^{[6
]}

Dombret, Herve ^{[7
]}

Fenaux, Pierre ^{[8
]}

Grimwade, David ^{[9
]}

Larson, Richard A. ^{[10
,11
]}

Lo-Coco, Francesco ^{[12
,13
]}

Naoe, Tomoki ^{[14
]}

Niederwieser, Dietger ^{[15
]}

Ossenkoppele, Gert J. ^{[16
]}

Sanz, Miguel A. ^{[17
]}

Sierra, Jorge ^{[18
]}

Tallman, Martin S. ^{[19
]}

Loewenberg, Bob ^{[20
]}

Bloomfield, Clara D. ^{[21
]}

机构：

[1] Univ Ulm, Dept Internal Med 3, D-89081 Ulm, Germany

[2] Seattle Canc Ctr Alliance, Seattle, WA USA

[3] Tor Vergata Univ Hosp, Dept Hematol, Rome, Italy

[4] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

[5] Univ Munster, Dept Hematol Oncol, Munster, Germany

[6] Cardiff Univ, Dept Haematol, Cardiff CF4 4XN, S Glam, Wales

[7] Hop St Louis, AP HP, Inst Univ Hematol, Paris, France

[8] Hop Avicenne, Serv Hematol Clin, F-93009 Bobigny, France

[9] Guys Kings & St Thomas Sch Med, Dept Med & Mol Genet, London, England

[10] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[11] Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA

[12] Univ Tor Vergata, Dept Biopathol, Rome, Italy

[13] Ctr Europeo Ric Cervello, Santa Lucia Fdn, Rome, Italy

[14] Nagoya Univ Hosp, Dept Hematol, Showa Ku, Nagoya, Aichi, Japan

[15] Univ Leipzig, Dept Hematol Oncol & Hemostasis, Leipzig, Germany

[16] Vrije Univ Amsterdam, Med Ctr, Dept Haematol, Amsterdam, Netherlands

[17] Univ Hosp La Fe, Hematol & Bone Marrow Transplant Unit, Valencia, Spain

[18] Hosp Santa Creu & Sant Pau, Dept Clin Hematol, Barcelona, Spain

[19] Northwestern Univ, Div Hematol Oncol, Feinberg Sch Med, Chicago, IL 60611 USA

[20] Erasmus Univ, Med Ctr, Dept Hematol, Rotterdam, Netherlands

[21] Ohio State Univ, Ctr Comprehens Canc, Arthur G James Canc Hosp, Columbus, OH 43210 USA

来源：

BLOOD | 2010年 / 115卷 / 03期

关键词：

STEM-CELL TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; COLONY-STIMULATING FACTOR; HIGH-DOSE CYTARABINE; BONE-MARROW-TRANSPLANTATION; RISK MYELODYSPLASTIC SYNDROME; TYROSINE KINASE INHIBITOR; MINIMAL-RESIDUAL-DISEASE; 1ST COMPLETE REMISSION; BALANCED CHROMOSOME-ABERRATIONS;

D O I：

10.1182/blood-2009-07-235358

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed. (Blood. 2010; 115: 453-474)

引用

页码：453 / 474

页数：22

共 313 条

[1]

ADRIAANSEN HJ, 1993, BLOOD, V81, P3043

[2] Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study [J].

Amadori, S ;

Suciu, S ;

Jehn, U ;

Stasi, R ;

Thomas, X ;

Marie, JP ;

Muus, P ;

Lefrère, F ;

Berneman, Z ;

Fillet, G ;

Denzlinger, C ;

Willemze, R ;

Leoni, P ;

Leone, G ;

Casini, M ;

Ricciuti, F ;

Vignetti, M ;

Beeldens, F ;

Mandelli, F ;

De Witte, T .

BLOOD, 2005, 106 (01) :27-34

[3] Balanced chromosome abnormalities inv(16) and t(15;17) in therapy-related myelodysplastic syndromes and acute leukemia: Report from an international workshop [J].

Andersen, MK ;

Larson, RA ;

Mauritzson, N ;

Schnittger, S ;

Jhanwar, SC ;

Pedersen-Bjergaard, J .

GENES CHROMOSOMES & CANCER, 2002, 33 (04) :395-400

[4] Stem cell transplantation for secondary acute myeloid leukemia: Evaluation of transplantation as initial therapy or following induction chemotherapy [J].

Anderson, JE ;

Gooley, TA ;

Schoch, G ;

Anasetti, C ;

Bensinger, WI ;

Clift, RA ;

Hansen, JA ;

Sanders, JE ;

Storb, R ;

Appelbaum, FR .

BLOOD, 1997, 89 (07) :2578-2585

[5] Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group study [J].

Anderson, JE ;

Kopecky, KJ ;

Willman, CL ;

Head, D ;

O'Donnell, MR ;

Luthardt, FW ;

Norwood, TH ;

Chen, IM ;

Balcerzak, SP ;

Johnson, DB ;

Appelbaum, FR .

BLOOD, 2002, 100 (12) :3869-3876

[6] Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT) [J].

Aoudjhane, M ;

Labopin, M ;

Gorin, NC ;

Shimoni, A ;

Ruutu, T ;

Kolb, HJ ;

Frassoni, F ;

Boiron, JM ;

Yin, JL ;

Finke, J ;

Shouten, H ;

Blaise, D ;

Falda, M ;

Fauser, AA ;

Esteve, J ;

Polge, E ;

Slavin, S ;

Niederwieser, D ;

Nagler, A ;

Rocha, V .

LEUKEMIA, 2005, 19 (12) :2304-2312

[7] Age and acute myeloid leukemia [J].

Appelbaum, FR ;

Gundacker, H ;

Head, DR ;

Slovak, ML ;

Willman, CL ;

Godwin, JE ;

Anderson, JE ;

Petersdorf, SH .

BLOOD, 2006, 107 (09) :3481-3485

[8] The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations [J].

Appelbaum, Frederick R. ;

Kopecky, Kenneth J. ;

Tallman, Martin S. ;

Slovak, Marilyn L. ;

Gundacker, Holly M. ;

Kim, Haesook T. ;

Dewald, Gordon W. ;

Kantarjian, Hagop M. ;

Pierce, Sherry R. ;

Estey, Elihu H. .

BRITISH JOURNAL OF HAEMATOLOGY, 2006, 135 (02) :165-173

[9]

ARLIN Z, 1990, LEUKEMIA, V4, P177

[10] Impact of cytogenetics on outcome of de novo and therapy-related AML and MDS after allogeneic transplantation [J].

Armand, Philippe ;

Kim, Haesook T. ;

DeAngelo, Daniel J. ;

Ho, Vincent T. ;

Cutler, Corey S. ;

Stone, Richard M. ;

Ritz, Jerome ;

Alyea, Edwin P. ;

Antin, Joseph H. ;

Soiffer, Robert J. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2007, 13 (06) :655-664

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