Synthesis of 6-methyl[C-11]-2'-deoxyuridine and evaluation of its in vivo distribution in Wistar rats

被引：5

作者：

Goethals, P

Volders, F

VanderEycken, J

vanEijkeren, M

Lemahieu, I

Dams, R

机构：

[1] STATE UNIV GHENT,DEPT ORGAN CHEM,B-9000 GHENT,BELGIUM

[2] STATE UNIV GHENT HOSP,DEPT RADIOTHERAPY & NUCL MED,B-9000 GHENT,BELGIUM

[3] STATE UNIV GHENT,DEPT ELECT & INFORMAT SYST,B-9000 GHENT,BELGIUM

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1997年 / 24卷 / 08期

关键词：

6-methyl[C-11]-2'-deoxyuridine; 6-M[C-11]UdR; synthesis; cell proliferation; methyl-C-11]thymidine; methyl-C-11]TdR;

D O I：

10.1016/S0969-8051(97)00110-8

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In this study, 6-methyl-2'-deoxyuridine, an artificial nucleoside, was labeled with C-11 in the methyl position. Tissue distribution of 6-methyl[C-11]-2'-deoxyuridine was investigated in normal Wistar rats and compared to the behavior of the natural nucleoside [methyl-C-11]thymidine. High renal clearance, up to at least 20% of the injected activity, was noticed during the 20 min period following injection. Tissue distribution as determined by dynamic PET studies of both C-11-labeled nucleosides was significantly different for most of the organs. (C) 1997 Elsevier Science Inc.

引用

页码：713 / 718

页数：6