Synthesis of 6-methyl[C-11]-2'-deoxyuridine and evaluation of its in vivo distribution in Wistar rats

被引：5
|
作者：
Goethals, P
Volders, F
VanderEycken, J
vanEijkeren, M
Lemahieu, I
Dams, R
机构：
[1] STATE UNIV GHENT,DEPT ORGAN CHEM,B-9000 GHENT,BELGIUM
[2] STATE UNIV GHENT HOSP,DEPT RADIOTHERAPY & NUCL MED,B-9000 GHENT,BELGIUM
[3] STATE UNIV GHENT,DEPT ELECT & INFORMAT SYST,B-9000 GHENT,BELGIUM
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1997年 / 24卷 / 08期
关键词：
6-methyl[C-11]-2'-deoxyuridine; 6-M[C-11]UdR; synthesis; cell proliferation; methyl-C-11]thymidine; methyl-C-11]TdR;
D O I：
10.1016/S0969-8051(97)00110-8
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
In this study, 6-methyl-2'-deoxyuridine, an artificial nucleoside, was labeled with C-11 in the methyl position. Tissue distribution of 6-methyl[C-11]-2'-deoxyuridine was investigated in normal Wistar rats and compared to the behavior of the natural nucleoside [methyl-C-11]thymidine. High renal clearance, up to at least 20% of the injected activity, was noticed during the 20 min period following injection. Tissue distribution as determined by dynamic PET studies of both C-11-labeled nucleosides was significantly different for most of the organs. (C) 1997 Elsevier Science Inc.
引用
收藏
页码：713 / 718
页数：6
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