Neonatal outcomes of pregnancy complicated by idiopathic thrombocytopenic purpura

被引:22
作者
Ozkan, H. [1 ]
Cetinkaya, M. [1 ]
Koksal, N. [1 ]
Ali, R. [2 ]
Gunes, A. M. [3 ]
Baytan, B. [3 ]
Ozkalemkas, F. [2 ]
Ozkocaman, V. [2 ]
Ozcelik, T. [2 ]
Gunay, U. [3 ]
Tunali, A. [2 ]
Kimya, Y. [4 ]
Cengiz, C. [4 ]
机构
[1] Uludag Univ, Sch Med, Dept Pediat, Div Neonatol, TR-16059 Gorukle, Bursa, Turkey
[2] Uludag Univ, Sch Med, Dept Internal Med, Div Hematol, TR-16059 Gorukle, Bursa, Turkey
[3] Uludag Univ, Sch Med, Dept Pediat, Div Pediat Hematol, TR-16059 Gorukle, Bursa, Turkey
[4] Uludag Univ, Sch Med, Dept Obstet & Gynecol, TR-16059 Gorukle, Bursa, Turkey
关键词
idiopathic thrombocytopenic purpura; ITP; pregnancy; neonatal thrombocytopenia; neonatal outcome; RISK; MANAGEMENT; MOTHERS; WOMEN;
D O I
10.1038/jp.2009.134
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The aim of this study was to determine the factors associated with the prognosis of newborns born to mothers with idiopathic thrombocytopenic purpura (ITP), and to compare the infants with/without thrombocytopenia in terms of maternal and neonatal characteristics. Study Design: We reviewed the charts of 29 parturients with ITP and their newborns who were born between January 1998 and December 2008. Result: A total of 16 (55%) gravidas had been diagnosed with ITP before pregnancy and 13 (45%) were diagnosed during pregnancy. Thrombocytopenia was observed in 21 gravidas. In total, 17 (58%) gravidas received treatment to increase the platelet count. The majority of deliveries (72.5%) were vaginal. The infant platelet counts at birth ranged from 20 to 336 x 10(9) per liter. None of the neonates had complications attributable to the mode of delivery. Normal platelet counts were determined in 15 newborns, whereas 14 infants had thrombocytopenia at birth. Three (10.3%) neonates had mild, four neonates (13.7%) had moderate and seven neonates (24.1%) had severe thrombocytopenia. The age of the mothers having infants with thrombocytopenia was significantly higher (30 +/- 5.3 vs 25.3 +/- 3.8 years), most of the infants (10/14 (71%)) were males (P<0.05). Conclusion: Pregnancy complicated with ITP generally has a good outcome. Although ITP in pregnancy carries a low risk, careful observation is required for the newborn of gravidas with ITP even when the infant has no bleeding complications at delivery, and infants may require treatment for thrombocytopenia. Journal of Perinatology (2010) 30, 38-44; doi: 10.1038/jp.2009.134; published online 24 September 2009
引用
收藏
页码:38 / 44
页数:7
相关论文
共 25 条
[1]   Pregnancy-associated thrombocytopenia revisited: Assessment and follow-up of 50 cases [J].
Ajzenberg, N ;
Dreyfus, M ;
Kaplan, C ;
Yvart, J ;
Weill, B ;
Tchernia, G .
BLOOD, 1998, 92 (12) :4573-4580
[2]   Idiopathic thrombocytopenic purpura in pregnancy:: a single institutional experience with maternal and neonatal outcomes [J].
Ali, R ;
Özkalemkas, F ;
Özçelik, T ;
Özkocaman, V ;
Ozan, Ü ;
Kimya, Y ;
Köksal, N ;
Bülbül-Baskan, E ;
Develioglu, O ;
Tüfekçi, M ;
Tunali, A .
ANNALS OF HEMATOLOGY, 2003, 82 (06) :348-352
[3]   RISK OF THROMBOCYTOPENIA IN THE INFANTS OF MOTHERS WITH IDIOPATHIC THROMBOCYTOPENIA [J].
ALMOFADA, SM ;
OSMAN, MEE ;
KIDES, E ;
ALMOMEN, AKMS ;
ALHERBISH, AS ;
ALMOBAIREEK, K .
AMERICAN JOURNAL OF PERINATOLOGY, 1994, 11 (06) :423-426
[4]   Maternal antiplatelet antibodies in predicting risk of neonatal thrombocytopenia [J].
Boehlen, F ;
Hohlfeld, P ;
Extermann, P ;
De Moerloose, P .
OBSTETRICS AND GYNECOLOGY, 1999, 93 (02) :169-173
[5]  
Borna Sedigheh, 2006, Arch Iran Med, V9, P115
[6]  
Burrows R F, 1993, Obstet Gynecol Surv, V48, P781, DOI 10.1097/00006254-199312000-00003
[7]   FETAL THROMBOCYTOPENIA AND ITS RELATION TO MATERNAL THROMBOCYTOPENIA [J].
BURROWS, RF ;
KELTON, JG .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (20) :1463-1466
[8]   THROMBOCYTOPENIA IN PREGNANCY [J].
BUSSEL, JB ;
DRUZIN, ML ;
CINES, DB ;
SAMUELS, P .
LANCET, 1991, 337 (8735) :251-251
[9]   Comparison of platelet counts in first and second newborns of mothers with immune thrombocytopenic purpura [J].
Christiaens, GCML ;
Nieuwenhuis, HK ;
Bussel, JB .
OBSTETRICS AND GYNECOLOGY, 1997, 90 (04) :546-552
[10]   Nationwide study of idiopathic thrombocytopenic purpura in pregnant women and the clinical influence on neonates [J].
Fujimura, K ;
Harada, Y ;
Fujimoto, T ;
Kuramoto, A ;
Ikeda, Y ;
Akatsuka, J ;
Dan, K ;
Omine, M ;
Mizoguchi, H .
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2002, 75 (04) :426-433